Hemato/Bioch Flashcards
According to the study on serum amyloid A (SAA) and plasma fibrinogen concentrations in horses after emergency exploratory celiotomy, which of the following statements are correct?
A. Serum amyloid A ([SAA]) concentrations peak 4 days post-surgery.
B. Plasma fibrinogen peaks 2 days post-surgery.
C. Lower [SAA] concentrations on day 5 post-surgery are associated with a better chance of survival.
D. Fibrinogen levels measured prior to surgery may predict post-operative complications.
E. Horses developing post-operative complications show a more intense and prolonged acute-phase response.
Answer choices:
A, B, C
B, C, E
A, D, E
C, D, E
A, B, E
Correct answer: 4. C, D, E
Explanation:
[SAA] peaks 2 days post-surgery (not 4 days), so A is incorrect.
Fibrinogen peaks 4 days post-surgery, so B is incorrect.
Lower [SAA] concentrations on day 5 are associated with a better chance of survival (C is correct).
Fibrinogen measured before surgery can help predict post-operative complications (D is correct).
Horses with post-operative complications show a more intense and prolonged acute-phase response (E is correct).
Serum amyloid A and plasma fibrinogen concentrations in horses following emergency exploratory celiotomy
M. DE COZAR* , C. SHERLOCK , E. KNOWLES and T. MAIR 2019
Based on the study evaluating serum amyloid A (SAA) concentrations in adult horses with bacterial pneumonia, which of the following statements are correct?
A. SAA concentrations decreased significantly over time and were highly correlated with changes in white blood cell (WBC) and neutrophil counts, as well as plasma fibrinogen levels.
B. SAA concentrations peaked on day 2 and then significantly decreased over the course of treatment.
C. SAA concentration was a better indicator of clinical improvement than WBC, neutrophil counts, and plasma fibrinogen levels, which did not show significant changes over time.
D. The plasma fibrinogen concentration and WBC count showed statistically significant changes in line with SAA concentrations during treatment.
E. SAA concentration on day 0 was 537 µg/mL, and it increased to a geometric mean of 1038 µg/mL on day 2 before decreasing.
Answer choices:
A, C, D
B, C, E
A, B, E
B, D, E
A, D, E
Correct answer: 2. B, C, E
Explanation:
A is incorrect: There was no significant correlation between SAA concentration and WBC count, neutrophil count, or plasma fibrinogen levels.
B is correct: SAA concentrations peaked on day 2 and then significantly decreased over time during treatment.
C is correct: SAA concentration was a better indicator of clinical improvement than WBC, neutrophil counts, or plasma fibrinogen levels, which did not change significantly.
D is incorrect: WBC count and plasma fibrinogen did not show statistically significant changes over time.
E is correct: The SAA concentration on day 0 was 537 µg/mL and peaked at 1038 µg/mL on day 2 before decreasing as the horses responded to treatment.
Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia. Kate L. Hepworth-Warren1 | Krista Estell2 | Bobby Cowles3 |Deborah Amodie3 | Mark Crisman3 2023
Based on the study investigating the clinical usefulness of serum amyloid A (SAA) in diagnosing synovial structure involvement from acute limb injuries in horses, which of the following statements are correct?
A. Serum SAA concentrations were significantly different between horses with penetrating synovial trauma (Group 1) and those without (Group 2).
B. In horses with penetrating synovial trauma (Group 1), SAA concentrations positively correlated with fibrinogen concentrations and the percentage of neutrophils in synovial fluid.
C. SAA can be used as a sole diagnostic tool to confirm synovial structure involvement in acute limb injuries.
D. The study suggests that serum SAA is useful when synoviocentesis fails or is not possible, as it might support diagnosis.
E. There is no consensus on a single reference standard diagnostic test for confirming synovial structure involvement in limb injuries.
Answer choices:
A, C, E
B, D, E
A, B, C
A, D, E
Correct answer: 2. B, D, E
Explanation:
A is incorrect: Serum SAA concentrations were not significantly different between Group 1 (penetrating synovial trauma) and Group 2 (without synovial structure penetration).
B is correct: In Group 1, SAA concentrations positively correlated with fibrinogen concentrations and the percentage of neutrophils in synovial fluid.
C is incorrect: The study concluded that SAA cannot be used as a sole diagnostic tool for confirming synovial structure involvement.
D is correct: SAA may support diagnosis when synoviocentesis fails or is not possible.
E is correct: There is no consensus on a single reference standard diagnostic test for confirming synovial structure involvement; multiple diagnostic tools should be used in conjunction.
Systemic serum amyloid A in early (<24 h) diagnosis of acute synovial structure involvement in horses with penetrating limb injuries. A.C. Müller a,*, K. Büttner b, M. R¨ocken 2021
Which of the following statements best summarizes the findings and clinical implications of the study on plasma iron concentration in neonatal foals?
A) Plasma iron concentration in neonatal foals was significantly lower in sick foals with systemic inflammatory response syndrome (SIRS) compared to healthy foals, indicating its utility as an early inflammatory marker.
B) The study found high variability in plasma iron concentrations among healthy neonatal foals, with no significant difference between foals with SIRS and those without, suggesting that plasma iron concentration is not a useful prognostic marker for SIRS.
C) Plasma iron concentration had a positive correlation with age in neonatal foals, indicating that older foals have higher iron levels than younger foals, making it a reliable indicator of overall health.
D) The research demonstrated that plasma iron concentration is a reliable early inflammatory marker, as it significantly decreased in response to various insults such as infection or trauma.
Correct Answer:
B) The study found high variability in plasma iron concentrations among healthy neonatal foals, with no significant difference between foals with SIRS and those without, suggesting that plasma iron concentration is not a useful prognostic marker for SIRS.
Justifications:
A) is incorrect because the study did not find lower plasma iron concentrations in sick foals compared to healthy foals; in fact, there was no significant difference in iron levels.
B) is correct. This option accurately reflects the key findings: there was high variability in plasma iron concentrations among healthy foals, and no significant difference was observed between SIRS and non-SIRS groups, indicating that plasma iron concentration is not useful for predicting SIRS.
C) is incorrect because the study reported a negative correlation between plasma iron concentration and age in neonatal foals, meaning that older foals did not have higher iron levels.
D) is incorrect because the research concluded that plasma iron concentration is not a reliable early inflammatory marker for neonatal foals, as it did not show significant changes in sick foals compared to healthy controls.
Sanmarti 2020 JVIM Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals
