Hepatitis Lecture - Schoeny Exam 3 Flashcards

1
Q

Which types of Hepatitis are spread through blood and body fluids? Which are spread through feces?

A

Blood/body fluids: B, C, D

Feces: A, E

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2
Q

Which types of hep cause chronic infection?

A

B, C, D

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3
Q

Which types of hep have a immunization?

A

A, B, D

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4
Q

Symptoms of acute hepatitis?

A

Nausea, vomiting, abd pain, loss of appetite, fever, diarrhea, light (clay) colored stools, dark urine, jaundice

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5
Q

There are 2 lab tests for hep a, hep A IgG, and hep A IgM. What’s the difference?

A

IgG tests for immunity from vaccine or previous infection

IgM tests for acute infection

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6
Q

What vaccines are available for hep A?

A

Havrix for hep A only

Twinrix is hep A/B combo

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7
Q

What is the immunization schedule for Havrix?

A

Children and adolescents - .5mL dose, 2 shot series given 6 months apart
Adults - 1mL dose, 2 shot series given 6 months apart

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8
Q

What is the immunization schedule for twinrix?

A

Standard - 3 shot series given at day 0, 1 month, and 6 months
Accelerated - 4 shot series given at day 0, day 7, day 21, and 1 year.

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9
Q

Hepatitis A treatment?

A

Supportive care

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10
Q

What is the most easily transmissible blood borne pathogen?

A

Hep B

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11
Q

When is the accelerated schedule for twinrix used?

A

For adults who are not immunized.

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12
Q

Can hep B be transmitted through breastmilk?

A

No

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13
Q

Most common hep B modes of transmission?

A

Sexual
Parenteral (needles)
Perinatal

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14
Q

What percentage of Hep B infections clear naturally?

A

80%

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15
Q

When Hep B + mothers give birth, what should be given to the baby at birth?

A

Hep B antibodies and hep b immunization

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16
Q

What patient population has increased risk of poor hep B outcomes?

A

patients of Asian descent

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17
Q

What are the different hepatitis B labs?

A
HBsAg
Anti-HBs
Anti-HBc
IgM anti-HBC
HBeAg
Anti-HBe
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18
Q

What is HBsAg?

A

Hep B surface antigen.

+ during infection

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19
Q

What is Anti-HBs, what does a + result indicate?

A

Antibody to HBsAg

Indicates immunity to Hep B. Does not specify if it is from infection or immunization.

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20
Q

What is Anti-HBc, what does a + result indicate?

A

Antibody to Hep B core antigen.

+ result indicates prior infection.

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21
Q

What is IgM anti-HBc, what does + result indicate?

A
IgM class antibodies to Hep B core antigen.
\+ result indicates infection within past 4-6 months.
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22
Q

HBeAg and Anti-HBe are used for what?

A

Specialized hep B treatment

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23
Q

What is the first detectable lab abnormality during hep B infection. When does it become postive?

A

HBsAg - positive 4 weeks after exposure.

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24
Q

Chronic hep B infection would show what lab abnormalities?

A

HBsAg and Anti-HBc would be positive.

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25
Q

An acute hep B infection would show what lab abnormalities?

A

+ HBsAg, Anti-HBc, and IgM anti-HBc

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26
Q

A patient immune to Hep B from immunization would have what + lab(s)?

A

Anti-HBs

27
Q

What two hep B vaccines are approved in newborns and above?

A

Engerix and recombivax

28
Q

Immunization schedule for engerix and recombivax?

A

3 dose series at 0, 1-2, and 4-6 months

29
Q

What Hep B vaccine is a 2 dose series is only approved for ages 18 and up? Immunization schedule?

A

Heplisav-2

given at day 0 and 1 month

30
Q

What is the leading cause of liver cancer and liver transplant in the US?

A

Hep C

31
Q

Is hep C curable?

A

Yes :)

32
Q

Is hep C vaccine preventable?

A

No :(

33
Q

Average hep C incubation peroid?

A

6-7 weeks

34
Q

What are some factors that lead to a worse prognosis in hep C infections?

A
Alcohol intake
Age > 40 at time of infection
HIV co-infection
Male gender
Chronic Hep B co-infection
35
Q

CDC recommends Hep C testing for people who received clotting factors before 1987 or blood/organs before 1992. Why?

A

Hep C was not discovered yet, so blood donations could not be screened for it.

36
Q

What labs are used to test for hep C?

A

Hep C antibody - screening test

HCV PCR - confirmatory test

37
Q

How many genotypes of hep C are there?

A

6

38
Q

Which hep C genotype is most common in the US?

A

Genotype 1 (80%)

39
Q

Hep A treatment

A

Supportive care

40
Q

Hep B treatment

A

Adefovir, entecavir, or tenofivir

41
Q

There are many hep C treatments. What is “the backbone of what we use today”?

A

Hep C polymerase inhibitors used with pegylated interferon and ribavirin

42
Q

List some of the Hep C polymerase inhibitors.

A

Simeprevir

Sofosbovir

43
Q

What test needs to be done prior to treating hep C with zepateir?

A

Test for NS5A resistance in genotype 1a

44
Q

Most common organism causing infectious esophagitis?

A

Candida albicans

45
Q

What are common viral causes of infectious esophagitis?

A

CMV or herpes virus

46
Q

Infectious esophagitis is common in _______ patients

A

Immunosuppressed

47
Q

Diagnosis of infectious esophagitis is made with ______

A

endoscopy

48
Q

Treatment for C albicans infectious esophagitis?

A

Diflucan

49
Q

Treatment for CMV infectious esophagitis?

A

Ganciclovir *** Only use if you are 100% sure its CMV because ganciclovir is toxic.

50
Q

Treatment for HSV infectious esophagitis?

A

Acyclovir

51
Q

Name this bacteria:

Gram negative rod residing in mucous gel coating of epithelial cells of the stomach.

A

H. pylori

52
Q

What conditions are H. pylori associated with?

A

PUD
Gastric adenocarcinoma
MALT cell lymphoma

53
Q

What tests are available for H pylori?

A

Stool antigen
Urea Breath test
Endoscopy with biopsy

54
Q

Treatment for H. pylori?

A

Clarithromycin, amoxicillin, and PPI

55
Q

Due to resistance, what substitutions may be made in the typical H pylori treatment?

A

May substitute either clarithromycin or amoxicillin with doxycycline or metronidazole.

56
Q

What quadrant is the pain from diverticulitis normally?

A

LLQ

57
Q

Treatment of diverticulitis?

A

Metronidazole and fluoroquinolone

58
Q

T/F? A botulism infection can be caused by 1 single spore.

A

true, it is highly virulent

59
Q

Botulism toxin causes descending flaccid paralysis by what mechanism?

A

Toxin prevents release of ACh at neuromuscular junction

60
Q

What food is often associated with botulism?

A

Home canned products

61
Q

Does botulism have a rapid or gradual onset?

A

rapid

62
Q

Treatment of botulism?

A

ICU admission
induce vomiting
Antitioxin!!!!! - gotta get it from the CDC

63
Q

What is tinea soleum?

A

Pork tapeworm

64
Q

What infection that lives in water and migrates to the urinary tract is linked to bladder cancer?

A

Schistosomiasis hematomium