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GI > Hepatitis B > Flashcards

Hepatitis B Flashcards

1
Q

What is the earliest indicator of Hep B infection?

A

Hep B surface antigen

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2
Q

How soon does the Hep B surface antigen appear?

A

Generally appears between 27-41 days but could appear as soon as 14 days

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3
Q

Does the Hep B surface antigen persist during the acute illness?

A

Yes

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4
Q

When does the Hep B surface antigen disappear?

A

1-13 weeks after the onset of biochemical abnormalities

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5
Q

What is the most reliable serologic marker of Hep B infection?

A

Hep B surface antigen

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6
Q

Can Hep B surface antigen be present in chronic infection?

A

Yes

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7
Q

Does Hep B vaccination result in a positive Hep B surface antigen?

A

No

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8
Q

What does the presence of the antibody to Hep B surface antigen indicate?

A

Clinical recovery and immunity to Hep B virus

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9
Q

Is the antibody to Hep B surface antigen present in chronic carriers?

A

No

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10
Q

What three things could Antibody to Hep B surface antigen without presence of Hep B surface antigen indicate?

A

Recovery from HBV infection
Absence of infectivity
Immunity from future HBV infection (i.e succesful immunisation)

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11
Q

What does the presence of a Hep B e antigen indicate?

A

A highly infectious state

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12
Q

How soon does Hep B e antigen appear?

A

Within one week of HB surface antigen.

In acute cases Hep B e antigen disappears before HB surface antigen disappears.

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13
Q

Can Hep B e antigen be found without Hep B surface antigen?

A

No

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14
Q

What does it suggest if Hep B e antigen persists for longer than 10 weeks

A

Progression to chronic carrier state and possible chronic hepatitis

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15
Q

What does the antibody to Hep B e antigen indicate?

A

Decreasing infectivity

It suggests a good prognosis and resolution of the acute infection

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16
Q

What does the presence of the antibodies for Hep B c and e antigens in the absence of the antibody for Hep B surface antigen and the hep B surface antigen confirm?

A

Recent acute infection

17
Q

What antibodies are produced in response to the Hep B core antigen (HB-c)

A

IgM and IgG

18
Q

What do a) high titres and b) low titres of IgM indicate in Hep B infection?

A

a) Acute infection

b) ongoing disease, usually chronic active hepatitis

19
Q

How soon does IgM appear after Hep B surface antigen?

A

4-10 weeks

20
Q

What is the only test that can differentiate between recent and remote Hep B infection on one specimen?

A

IgM

21
Q

What is indicated when there is IgG anti-HBc and the HB surface antigen?

A

chronic HBV hepatitis

22
Q

What does IgG anti-HBc without the HB surface antigen indicate?

A

Infection in the remote past

23
Q

What does presence of HBV DNA indicate?

How is it detected?

A

Continued infectious state

PCR

GI (59 decks)

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