Gastroenteritis Flashcards

1
Q

Define gastroenteritis

A

Syndrome of diarrhoea and vomiting that refers to non-inflammatory involvement of the upper small bowel or inflammation of the colon.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the most common cause of gastroenteritis?

A

Infection.
The vast majority is caused by a virus.
Bacteria - 20%
Parasites < 6%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What percentage of gastroenteritis cases are not infectious?

A

15%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Give some non-infectious diarrhoea examples

A
GI bleed
Ischaemic gut
Diverticulitis
Endocrine disorders
Numerous drugs
Fish toxins
WIthdrawal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the approach to any clinical infection syndrome?

A

What are the key clinical symptoms and signs that suggest the infection?
Differential diagnosis
Severity of Infection
Site and microbiological diagnosis: investigations
Antibiotic and supportive management
Infection Control
Public Health

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is another name for the norovirus?

A

Norwalk agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which pathogens cause toxin-mediated food poisoning?

Which of these pathogens pre form toxins and which are formed in vivo?

A
Preformed:
Staph aureus
Clostridium perfringens
Bacillus cereus
In vivo production:
Vibrio
Enterotoxigenic E. coli
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the presenting clinical syndromes of food poisoning?

A
1. Acute enteritis (i.e. inflammation of the small intestine):
Fever
Diarrhoea
Vomiting
Abdominal pain
2. Acute colitis:
Fever
Pain
Bloody diarrhoea
3. Enteric fever-like illness:
Fever
Rigors
Pain
Little diarrhoea
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

List infective and non-infective causes of bloody diarrhoea

A
Infection:
bloody diarrhoea usually indicates colonic inflammation
Campylobacter. spp
Shigella. spp
E. coli 0157
Amoebiasis

Non infective:
IBD
Malignancy
Ischaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Describe the symptoms of enteric fever-like illness

A

Fever
Systemically unwell
Abdominal pain
Constipation but possibly short history of diarrhoea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is typhoid?

A

A bacterial infection that can spread throughout the body involving multiple organs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where does Typhoid come from?

A

It is almost always imported
From:
Indian subcontinant, South East Asia, Far east, middle east, Africa, central/south america, Increasing in Eastern Europe.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is typhoid transmitted?

A

Food, water or carrier

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How can typhoid present?

A

It can be asymptomatic
It can be mild
It can cause bacteraemia
it can cause enterocolitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How is typhoid diagnosed?

A

Blood cultures are the key to diagnosis.

Stool and urine cultures also done.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How is typhoid treated?

A

Chloramphenicol and ciprofloxacin- some strains resistant to this
Ceftriaxone or azithromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How can typhoid be prevented?

A

There is an IV or oral vaccine.

It is not effective against paratyphoid.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are key features in a gastroenteritis history?

A

Diarrhoea: frequency, nocturnal, constistency, colour, presence of blood
Associated symptoms: abdominal pain, vomiting, fever, urgency, incontinence
Anyone in family or work with similar symptoms
Occupation
Pets and animal contact
Travel abroad
History of medication- particularly recent Abx and PPIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are key features in a gastroenteritis examination?

A

Fever
Skin rashes, e.g. rose spots, erythema nodosum
Dehydration: pulse, mental state, dry tongue, skin turgor, blood pressure, postural drop
Abdominal tenderness
Abdominal distension
PR exam: stool, blood, tenderness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What investigations are carried out to help diagnosis a gastroenteritis?

A

Stool microscopy when appropriate (e.g. history of travel, for giardia, amoeba etc)
Stool culture: Salmonella, Camppylobacter, Shigella
Stool toxin for C diff (culture not routinely done), adn cytotoxin for E. coli
Blood cultures (salmonella)
PCR : .e.g norovirus
FBC- wcc key in severity of CDI
U, Es - renal function important
AXR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are severity markers of CDI?

A

One or more of the following:
Suspicion of PMC or toxic megacolon or ileus or colonic dilatation in CT/AXR of >6cm
WCC > 15 cells/mm3
Creatinine > 1.5 x baseline

22
Q

What are intestinal complications of bacterial enteritis?

A

Severe dehydration and renal failure
Acute colitis, toxic dilatation
Post infective irritable bowel
Transient secondary lactase intolerance

23
Q

What are extra-intestinal complications of bacterial enteritis?

A
Septicaemia
Metastatic infection: meningitis, aortitis, osteomyelitis, endocarditis
Reactive arthritis
Meningism
Neurological- Guillian-Barre syndrome
haemolytic uraemic syndrome
24
Q

What is supportive treatment for gastroenteritis?

A
Oral rehydration
IV fluids (saline important)
25
What is specific treatment for gastroenteritis?
Anti-spasmodics Anti-motility agents Antibiotics- only in specific situations
26
Name 2 antisecretory antidiarrhoeal agents
Chlorpromazine | Bismuth subsalycilate
27
Name 2 absorbant antidiarrhoeal agents
kaolin | charcoal
28
When are patients given empirical antibiotic therapy for gastroenteritis?
1. They must have 3 or more unformed stools per day as well as one or more of: abdominal pain, nausea, vomiting, fever, blood in stool, tenesumus 2. As well as 1, patients must either a) be high risk: immunocomprimised hypochlorhydria inflammatory bowel disease prosthetic intravascular device or b) have dysenteric symptoms: fever bloody diarrhoea abdominal pain 3. A stool sample or rectal swab for culture is taken from these patients 4. Patients are given ciprofloxacin 500mg BD for 3-5 days and their progress is reviewed
29
What kind of bacterium is C difficile?
Anaerobic gram positive spore forming bacillus
30
What are risk factors for C diff infection?
Antibiotics: All, but greatest risk with broad spectrum e.g. fluoroquinolones, cephalosporins, clindamycins, broad spectrum penicillins Medications: PPI H2RA Advanced age - at least 65 years old Chemotherapy, chronic renal disease, underlying IBD
31
What drugs should be avoided in pseudomembrinous colitis?
Antibiotics which may be precipitating it opiates Anti-peristaltic drugs PPIs
32
What is the treatment for pseudomembranous colitis?
Oral therapy more reliable than parenteral therapy Non-severe: metronidazole Severe/failure of metronidazole: vancomycin Do not use IV vancomycin
33
What is the treatment for the 1st presentation of uncomplicated CDI?
``` Oral metronidazole for 14 days Stop other antibiotics Review PPIs Dont use anti-motility agents No re testing unless symptomatic Should improve within 3-5 days ```
34
What is the treatment for CDI if it responds poorly to oral metronidazole, if the disease is severe, or if there is more than one severity marker?
Get help Start oral vancomycin 125mg qds 10-14 days Vancomycin isn't absorbed so stays in the bowel to kill bacteria
35
Why can C diff infection relapse?
Because although the bacteria are killed, they can leave behind spores
36
What should be considered in persistent diarrhoea that lasts for more than a week?
Parasites | Screen for IBD
37
Should antibiotics be used to treat Ecoli 0157?
No
38
Which pathogens cause travel-related diarrhoea?
Amoebiasis Giardiasis Cryptosporadiasis
39
What is the average duration of untreated traveller's diarrhoea?
4 days
40
How long can traveller's diarrhoea persist for?
Up to 2 months, but this is only in 1-2% of people
41
What is amoebiasis? How is it spread? How is it diagnosed?
A protozoal infection It is spread by faeco-oral route or by an ill or asymptomatic carrier Diagnosed by examination of hot stool for ova and cyts. Serology may be of use, especially in extra-intestinal disease
42
What can amoebiasis cause?
Acute bloody diarrhoea | Extra-intestinal spread to produce an abscess can occur
43
What is giardiasis?
Protozoon Giardia lambia trophozoites colonizes the small bowel mucosa to produce diarrhoea and malabsorption; often explosive, protracted and foul smelling
44
How is giardiasis spread?
Infection spread by cysts found in normal drinking water
45
How is Giardiasis diagnosed?
Diagnosis is examination of stools for ova and cysts but more accurately by duodenal aspiration
46
What is an important cause of traveller's diarrhoea?
enterotoxigenic E coli
47
What is Cryptosporidiosis?
A parasitic disease cryptosporidium, which is a protozoan parasite.
48
How is Cryptosporidiosis transmitted?
Water, food, contact with animals. It is highly infectious and resilient.
49
Does Cryptosporidiosis require treatment?
It is self limiting. | It is severe in immunosuppressed patients
50
How is Cryptosporidiosis diagnosed?
Duodenal aspirate/stool
51
What is the treatment for Cryptosporidiosis?
Supportive