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Phoebe's GI > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

Viruses

A

A, B, C, D & E

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2
Q

Hep A Transmission

A

Faecal Oral

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3
Q

Hep A people

A

Children, travellers, poor hygiene

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4
Q

Hep A clinical

A

Acute hepatitis

No chronic infection

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5
Q

Hep A lab

A

Clotted blood for serology
Hep A IgM = acute infection
Hep A IgG = previous infection, remains for life

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6
Q

Hep A symptoms

A

Fever, malaise, nausea, athraligia, jaundice + hepatomegaly, splenomegaly and lymphadenopathy

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7
Q

Hep E

A

Tropical
Like Hep A
Faecal oral

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8
Q

Hep D

A

Only found in Hep B virus, exacerbates

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9
Q

Hep B transmission

A

Sex
Mother to child
Blood
Chronic infection, first exposure as child

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10
Q

Hep B Ix

A

HBsAG present in blood of all infectious individuals
HBeAG often
Hep B IgM
Anti-HB’s in immunity

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11
Q

Hep B control

A

Minimise exposure:
Safe sex, needles, blood
Vaccines
HBIG (hyperimmune Hep B immunoglobulin)

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12
Q

Hep C transmission

A

Unprotected sex

Blood to blood

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13
Q

Hep C control

A

No vaccine

Minimise exposure

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14
Q

Management of acute viral hepatitis

A

Symptomatic
No antivirals given
Notify public health
Vaccinate against other infections if at risk

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15
Q

Management of chronic hepatits

A 
Antivirals
Vaccination
Infection control
Alchohol
Hepatocellular carcinoma awareness/screening
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16
Q

Inteferon alfa

A

Human protein
Part of immune response to viral infection
Given by injection

17
Q

PBC

A

IgM and anti-mitochondrial antibody

18
Q

Storage diseases

A

Haemochromatosis
Wilson’s Disease
Alpha-1-antitrypsin deficiency

19
Q

Haemochromatosis

A

Excess iron in liver

20
Q

Primary Haemochromatosis

A

Genetic condition
Increased absorption of iron
Autosomal reccessive

21
Q

Secondary Haemochromatosis

A

Iron overload from diet, transfusions, iron therapy

22
Q

Wilson’s disease

A

Inherited autosomal recessive disorder of copper metabolism
Copper accumulates in liver and brain
Causes chronic hep and neurological deterioration

23
Q

Alpha-1-antitrypsin deficiency

A

Inherited autosomal recessive
Disorder of production of enzyme inhibitor
Causes empyema and cirrhosis
Cytoplasmic globules of unsecreted globules of protein in liver cells

24
Q

Primary Liver Tumours

A

RARE
Hepatocellular adenoma
Hepatocellular carcinoma

25
Q

Secondary Liver Tumours

A

COMMON
Multiple
Metastases from colon, pancreas, stomach, breast, lung and others

26
Q

Hepatocellular Adenoma

A

Benign
Females
May become large (can rupture or bleed)
Most remain asymptomatic

Phoebe's GI (24 decks)

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