Hepatitis Flashcards

1
Q

What type of virus is Hepatitis A?

A

RNA picornavirus

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2
Q

How is Hepatitis A spread?

A

Spread by the faecal oral route of transmission

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3
Q

Is Hepatitis A treated?

A

No, it is self-limiting-resolves in 1-3 months with no treatment

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4
Q

What medication can be given for Hepatitis A?

A

Analgesia

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5
Q

What type of vaccine is a Hepatitis A vaccine?

A

Inactivated

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6
Q

Is there a vaccine for Hepatitis C?

A

No

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7
Q

In who does hepatitis c cause the most deaths?

A

IVDU’s

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8
Q

How is hepatitis c spread?

A

Parenteral
Sexual
Vertical transmission

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9
Q

What might hepatitis C cause?

A

Chronic hepatitis and cryoglobulinemia

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10
Q

What does Hepatitis C increase the risk of?

A

Hepatocellular carcinoma and cirrhosis

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11
Q

What is the management for acute hepatitis C?

A

Analgesia and supportive

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12
Q

What is the management of chronic hepatitis C?

A

Ribavirin

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13
Q

What does hepatitis D require to propagate?

A

Hepatitis B virus

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14
Q

What type of virus is RNA?

A

RNA

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15
Q

How is Hepatitis E spread?

A

• Spread by the faecal oral route of transmission

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16
Q

In who does hepatitis E have a high mortality rate?

A

Pregnant women

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17
Q

What antibodies would you find in autoimmune hepatitis?

A

ANA/SMA/LKM1 antibodies

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18
Q

What would be raised with autoimmune hepatitis?

A

Raised IgG levels

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19
Q

What is the management of autoimmune hepatitis?

A

Steroids and other immunosuppressants

e.g. azathioprine or Liver transplant

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20
Q

What type of vaccine is the hepatitis B vaccine?

A
21
Q

How is Hepatitis B spread?

A

Parenteral, sexual and vertical transmission route

22
Q

Who is Hepatitis B common in?

A

Intravenous drug users

23
Q

How does Hepatitis B present?

A

Flu-like prodrome which progresses to Fever, Jaundice and malaise

24
Q

How is Hepatitis B diagnosed?

A

Serology for Hep b

25
Q

How would you monitor Hepatitis B?

A

HBV-DNA (direct count of viral load)

26
Q

What is the management for acute Hepatitis B?

A

Supportive

27
Q

What is the management of chronic hepatitis B?

A

Pegylated interferon

28
Q

What is a possible complication of Hepatitis B?

A

Can progress to Hepatocellular carcinoma and cirrhosis

29
Q

How is the vaccine for hepatitis B administered?

A

Three doses then tested for HBsAb

30
Q

What is HBsAg?

A

Surface antigen

31
Q

What does HBsAg indicate?

A

Active infection

32
Q

What type of infection is it if HBsAg is present for less than 6 months?

A

Acute infection

33
Q

What type of infection is it if HBsAg is present for more than 6 months?

A
34
Q

What is HBsAb (anti-HBs) ?

A

Surface anti-body

35
Q

What does the surface antibody suggest?

A

Vaccination, past or current infection

36
Q

When would HBsAb be negative?

A

In a chronic infection

37
Q

What is HBeAg?

A

E antigen

38
Q

What does the E antigen indicate?

A

Marker of viral replication

39
Q

What does a high e antigen suggest?

A

The more infective they are

40
Q

What is HBcAB?

A

Core antibodies

41
Q

What do the core antibodies suggest?

A

Past or current infection

42
Q

What are the 2 types of core antibodies (HBcAB)?

A

IgM and IgG

43
Q

What do IgM core antibodies indicate?

A

Acute infection
High titre with acute infection
Low titre with chronic infection

44
Q

What do IgG core antibodies indicate?

A

Past infection where HBsAg is negative

45
Q

What immunisation results would you get with a previous immunisation?

A

HBsAg negative
Anti-HBs positive
Anti-HBc negative

46
Q

What immunisation results would you get from an acute infection?

A

HBsAg positive
Anti-HBs negative
IgM anti-HBc positive

47
Q

What immunisation results would you get with a chronic infection?

A

HBsAg positive
Anti-HBs negative
IgG anti-HBc positive
IgM anti-HBc negative

48
Q

What immunisation results would you get from a previous infection but not a carrier?

A

• Previous infection, not a carrier: HBsAg negative, anti-HBs positive, IgG anti-HBc positive