HEPATITES Flashcards

1
Q

funcoes do figado
depuracao de…
sintese de…

A

depuracao de:

  • toxinas (principal = amonia)
  • bilirrubina indireta (capta, conjuga e excreta)

sintese de:

  • glicose
  • albumina
  • fatores de coagulacao
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2
Q

hepatite viral aguda - tempo

A

<6 meses

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3
Q

hepatite viral cronica - tempo

A

> 6 meses

virus B e C
risco de cirrose

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4
Q

hepatite fulminante

A

encefalopatia em <8 sem

principalmente virus B

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5
Q

transmissao hep A

A

fecal-oral

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6
Q

tto hep A

A

nao faz! Ela cura sozinha

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7
Q

transmissao hep B

A

sexual (+comum)
vertical
percutanea
outras

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8
Q

unico virus da hepatite que nao e de RNA

A

Hep B (DNA)

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9
Q

indica presenca do virus B

A

HBsAg

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10
Q

indica que teve contato com o virus

A

Anti-HBc (IgM = recente)

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11
Q

indica protecao (cura ou vacinacao)

A

Anti-HBs

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12
Q

indica replicacao viral

A

HBeAg

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13
Q

indica que nao esta tendo replicacao viral

A

Anti-HBe

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14
Q

hep B aguda

A

HBsAg+
Anti HBs-
Anti HBs IgM +
Anti HBc IgG +/-

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15
Q

hep B cronica

A

HBsAg+
Anti HBs-
Anti HBc IgG+
Anti HBc IgM-

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16
Q

hist de hep B curada

A

HBsAg-
Anti HBs+
Anti HBC IgG+

17
Q

Vacinado p/ hep B

A

HBsAg-
Anti HBs+
Anti HBc IgG -

18
Q
Hep B com 
HBeAg -
HBsAg+
transaminases mt elevadas
....
pedi HBV-DNA e deu aumentado

pensar em:

A

hepatite B mutante pre core (falha na sintese do HBeAg)

variante mais agressiva, com risco de fulminante/cirrose/cancer

19
Q

tipo de hepatite que pode evoluir para CA sem passar pelo estagio da cirrose

A

virus B!

E o unico que e de DNA, entao ele consegue alterar mais facilmente o DNA do hepatocito

20
Q

tto hep B aguda

A

suporte, orientacao, acompanhamento

21
Q

tipo de hepatite que mais cronifica e tem mais chance de cirrose

A

virus C!
quase sempre assintomatico ate a cirrose

Obs: porem o virus B e o mais virulento

22
Q

principal fonte de contagio do virus C

A

“C de corte”

Drogas injetaveis!!

23
Q

indica infeccao em atividade

A

anti HCV+
+
HCV RNA +

24
Q

manifestacao extra hepatica da hepatite C

A

Crioglobulinemia

25
Q

Pct com hep C que desenvolve bolhas seguidas de erosoes e crostas em area de trauma e superficies fotoexpostas (principalmente dorso das maos e face)

A

porfiria cutanea tardia

26
Q

hep D

A

“D de Depende do B”
Coinfeccao = B+D agudas
Superinfeccao= B cronica + D aguda -> maior risco de fulminante e de cirrose