Hepatic Metabolism of Lipids Flashcards
What is arterial and venous pathway of blood in the liver?
A: Heart –> Abd Aorta –>PHA –> Liver
V: Liver –> HV –> IVC –> Heart
What is the haptic portal vein composed of?
SMV, IMV and Splenic Vein
What are 7 of the Liver’s main functions?
1) Detoxification: Filters and clean blood of waste
2) Immune Function: Fight infection and disease
3) Synthesis: CF, proteins, enzymes
4) Production of Bile, BD bilirubin
5) Energy storage (Glycogen and Fats)
6) Regulation of fat metabolism
7) Ability to regenerate
How does the liver maintain a continuous supply of energy?
Controlling metabolism of fats and CHO (carbohydrates)
What is the liver regulated by?
1) Endocrine Glands
2) Nerves
What are the 2 main ways fat is stored in body? (Concerning liver)
1) Adipocytes
2) Hepatocytes
What is the liver the main storage place for?
Glycogen
What are the 3 ways lipids accumulate in the liver?
1) Reduced export and oxidation
2) Increased FA influx from lipolysis and ^ de novo synthesis
3) Excess intake, TG in chylomicron remnants reach liver
Describe what a lipoprotein is
Core containing TG’s and cholesterol esters.
Surface monolayer of phospholipids, cholesterol and specific proteins
What fuels does the liver use?
Glucose, AA and FA
What is a TG broken down into?
Monoglycerides and 3 FA
What mechanism speeds up fat digestion?
Emulsification: SA for lipase action increased
What substances emulsify lipids?
Bile salts and phospholipids
What is steatosis?
Abnormal retention of fat within a cell/organ
What is the afferent and efferent vascular supply of liver?
A: Portal vein and HA
E: Hepatic Veins
