Exocrine Pancreas

Question 1

What are the 2 features of Exocrine secretion?

Answer 1

1) Aqueous Bicarbonate secretion

2) Enzyme Secreteion

Question 2

What is the pathway through the pancreatic duct?

Answer 2

Enzymes and fluid flow down into duodenum through ampulla of Vater

Question 3

What does pancreatic amylase do and break?

Answer 3

Do: Digests starch in SI
Break: Alpha 1-4 linkages

Question 4

What are the role and examples of proteases?

Answer 4

Digest proteins to AA

Trypsin/Chymotrypsin

Question 5

What is role of pancreatic lipase?

Answer 5

Triglyceride digestion by hydrolysis

Dietary fat absorption dependent on pancreatic and hepatic secretion

Question 6

What does amylase hydrolyse?

Answer 6

Starch to maltose and dextrins

Question 7

What are consequences of Exocrine dysfunction?

Answer 7

Malnutrition, Osteoporosis, Increased Cardiovascular morbidity, significant symptom burden

Question 8

How is Exocrine dysfunction treated?

Answer 8

1) Enzyme replacement
2) Assessment of Bone Health
3) Smoking Cessation
4) Treat underlying cause