hemophilia A

Question 1

classic hemophilia

Answer 1

Hemophilia A

Question 2

Prolonged bleeding is the main
symptom.

circumcised.

after surgery or injury

Bleeding into joints

Answer 2

Hemophilia A

Question 3

Activated Partial Thromboplastin Time

Prothrombin time

Answer 3

Hemophilia A Diagnosis (Tests & Procedures)

Question 4

● This test measures how long it takes for blood to clot.
● It measures the clotting ability of factors VIII, IX, XI, and XII.
● If any of these clotting factors are too low, it takes longer than normal for the blood to clot

Answer 4

Activated Partial Thromboplastin Time

Question 5

● This test also measures the time it takes for blood to clot
● It measures primarily the clotting ability of factors I, II, V, VII, and X
● If any of these factors are too low, it takes longer than normal for the blood to clot

Answer 5

Prothrombin time

Question 6

● Measures the activity of factor VIII in the blood.
● This test is typically ordered to evaluate and monitor clotting disorders, such as
hemophilia A.
● The normal range for factor VIII activity in the blood is usually between 50-150% of
normal.
● Low levels of factor VIII activity in the blood suggest a higher likelihood of Hemophilia A

Answer 6

Serum Factor VIII Activity

Question 7

no previous family
history of the disorder (spontaneously).

Answer 7

Hemophilia A

Question 8

changes (variants or mutations) to
the F8 gene located on the X
chromosome

Answer 8

Hemophilia A

Question 9

inherited or occur randomly with no previous family
history of the disorder (spontaneously)

Answer 9

Hemophilia A

Question 10

mostly expressed in males
but some females who carry the gene
variant may have mild or, rarely, severe
symptoms of bleeding

Answer 10

Hemophilia A