factor X Flashcards
passed down from parents to their children through
faulty genes
Inherited Factor X Deficiency
develop later in life due to liver disease, vitamin K
deficiency, certain medications, or autoimmune diseases
Acquired Factor X Deficiency
measure Factor X levels
and assess clotting function
- Prothrombin time (PT)
- Activated Partial Thromboplastin Time (aPTT)
- Factor X activity assay
Genetic testing may be used to determine if there are any mutations in the
genes responsible for producing Factor X
Blood Sample Collection
Preparation of Plasma
Addition of Reagent (thromboplastin reagent)
Incubation
Measurement of Clotting Time: measured using coagulation analyzer.
Comparison to Normal Values
Interpretation: If the clotting time is prolonged, it may indicate a deficiency in one or more factors
involved in the extrinsic pathway, including factor X.
Prothrombin time (PT)
results in a prolonged PT because factor X is necessary for the conversion of
prothrombin to thrombin in the coagulation cascade. Therefore, if there is a deficiency in factor X, the
conversion of prothrombin to thrombin is impaired, leading to delayed clot formation and a prolonged PT
Factor X deficiency
Blood Sample Collection
Preparation of Plasma
Addition of Activating Agent (e.g., kaolin)
Calcium Addition (activation of clotting factors, including factor X)
Measurement of Clotting Time: measured using coagulation analyzer.
Comparison to Normal Values
Interpretation: If the clotting time is prolonged beyond the normal range, it suggests a deficiency
or dysfunction in one or more clotting factors, including factor X.
Further Testing: If factor X deficiency is suspected based on the prolonged aPTT, additional tests
may be performed to confirm the diagnosis. These tests may include specific factor assays to
measure the activity or concentration of factor X directly.
Activated Partial Thromboplastin Time (aPTT)
