factor XIII

Question 1

blood’s ability to form stable blood clots.

Answer 1

Fibrin Stabilizing Factor Deficiency

Question 2

1. Clot Solubility Test
2. Clot Stability test
3. Genetic Testing

Answer 2

diagnose Factor XIII deficiency

Question 3

bleeding time test to assess their overall
clotting ability. Early diagnosis is essential to prevent complications such as
excessive bleeding or abnormal wound healing

Answer 3

Factor XIII deficiency

Question 4

Blood Sample Collection
Preparation of Plasma
Preparation of Clotting Solution
Clot Formation
Clot Lysis (Shorter CLT indicates higher fibrinolytic activity, suggesting efficient clot dissolution.
The longer CLT suggests impaired fibrinolytic activity, which may indicate potential coagulation
disorders or abnormalities in the fibrinolytic system.)
Data Collection
Calculate parameters such as clot lysis time, rate of clot dissolution, or any other relevant metrics
based on your experimental design.

Answer 4

Clot Solubility Test

Question 5

Sample Collection
Preparation of Plasma
Clot Formation
Clot Retraction
Clot Stability Assessment
Normal Result: A fully retracted clot suggests normal fibrinogen levels and clot stability. It indicates
that fibrinogen is present in sufficient quantities, and the clotting process is functioning properly.
Abnormal Result: Incomplete Retraction: If the clot shows partial or no retraction, it suggests
decreased fibrinogen levels or impaired clot stability. This may be indicative of conditions such as
hypofibrinogenemia, liver disease, or fibrinolysis disorders.
No Retraction: Absence of clot retraction may indicate severe fibrinogen deficiency or
dysfunction, as well as conditions such as disseminated intravascular coagulation (DIC) or
excessive fibrinolysis.

Answer 5

Clot Stability Test

Question 6

Patient Consultation and Consent:
Sample Collection
DNA Extraction
Targeted Sequencing or Genotyping
Whole Genome/ Exome Sequencing (Optional)
Data Analysis and Interpretation

Answer 6

Genetic Testing