HemOnc Drugs Flashcards

1
Q

ADR of ASA?

A

GI ulcers

Reye sx in kids

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2
Q

What is a type of antiplatelet?

A

clopidogrel

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3
Q

How does clopidogrel work?

A

antiplatelet
works well w/ASA
inhibits platelet activation

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4
Q

What is an anticoagulant? How to monitor?

A

warfarin

monitor: PT/INR

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5
Q

What are anticoagulation agent?

A

unfractionated heparin
LMWK-enoxaparin
direct factor Xa inhibitor - rivaroxaban
direct thrombin inhibitor - dabigatran

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6
Q

How to monitor unfractionated heparin? Reverse? ADR?

A

aPTT
reverse w/ protamine
HIT

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7
Q

What is good about enoxaparin? Reverse?

A

LMWH

  • more selective = more predictable
  • longer half life
    reverse: partially w/ protamine
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8
Q

Which turn off factor Xa?

A

unfractionated heparin
enoxaparin
rivaroxaban

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9
Q

What is bad about rivaroxaban?

A

no antidotes to reverse

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10
Q

What is good about dabigatran?

A

no lab monitoring needed

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11
Q

What is dabigatran?

A

anticoagulant

-direct thrombin inhibitor

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12
Q

What is 5-flurouracil? ADR?

A

fakes like a purine/pyrimidine by preventing DNA replication

ADR: cardiotoxic, alopecia, pancytopenia

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13
Q

What is methotrexate?

A

stops folic acid reductase

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14
Q

What to keep in mind about folic acid?

A

can mask b12 def

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