HemOnc Drugs Flashcards
ADR of ASA?
GI ulcers
Reye sx in kids
What is a type of antiplatelet?
clopidogrel
How does clopidogrel work?
antiplatelet
works well w/ASA
inhibits platelet activation
What is an anticoagulant? How to monitor?
warfarin
monitor: PT/INR
What are anticoagulation agent?
unfractionated heparin
LMWK-enoxaparin
direct factor Xa inhibitor - rivaroxaban
direct thrombin inhibitor - dabigatran
How to monitor unfractionated heparin? Reverse? ADR?
aPTT
reverse w/ protamine
HIT
What is good about enoxaparin? Reverse?
LMWH
- more selective = more predictable
- longer half life
reverse: partially w/ protamine
Which turn off factor Xa?
unfractionated heparin
enoxaparin
rivaroxaban
What is bad about rivaroxaban?
no antidotes to reverse
What is good about dabigatran?
no lab monitoring needed
What is dabigatran?
anticoagulant
-direct thrombin inhibitor
What is 5-flurouracil? ADR?
fakes like a purine/pyrimidine by preventing DNA replication
ADR: cardiotoxic, alopecia, pancytopenia
What is methotrexate?
stops folic acid reductase
What to keep in mind about folic acid?
can mask b12 def