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WHOLE PT > Endo Drugs > Flashcards

Endo Drugs Flashcards

1
Q

What is orlistat? What does it improve?

A

pancreatic lipase inhibitor

improves BP and lipid profiles

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2
Q

What reduces glucose absorption from the gut by preventing complex sugars from getting broken down? When to be given?

A

Acarbose

before meals

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3
Q

What is pioglitazone? Why is this bad but good?

A

thaizolidinediones

can take up to 12 wks to work but improved lipid profiles

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4
Q

What is Exenatide? How is it given?

A

GLP1 agonist
increases insulin ONLY when glucose is elevated
parenterally

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5
Q

What drug is insulin sensitizer on liver and muscle cell? Why is this drug good for DMII? Contraindicated in?

A

metformin
wt loss
kidney dz

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6
Q

Which drugs increase insulin secretion? Is it sulfo or nonsulfonylureas?

A

Glipizide - sulfonylurea

Repaglinide- nonsulfonylurea

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7
Q

What insulin is long acting? Onset? Duration?

A

Glargine

onset: 2-4hr
duration: 20-24hr

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8
Q

What insulin is intermediate acting? Onset? Duration?

A

NPH, isophane insulin

2-4hr; duration 10-16hr

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9
Q

What insulin is short acting? Onset?

A

regular insulin

30-60min

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10
Q

What are the 2 rapid acting insulin? Onset?

A

aspart
lispro
5-15min

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11
Q

Pt has initial a1c >9 -tx?

A

no sx: dual or triple therapy

sx: insulin

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12
Q

Pt has initial a1c of >7.5-tx?

A

lifestyle changes + dual therapy

-metformin + GLP, DPP4, Cromocriptine, AG

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13
Q

Pt has initial a1c of 7.5 or lower - tx?

A

lifestyle changes + monotherapy

  • metformin
  • GLP
  • DPP4
  • AG
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14
Q

What drug is contraindicated for pts w/ renal failure - DMII?

A

metformin

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15
Q

What is levothyroxine?

A

synthetic T4 so it can turn into T3

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16
Q

When should levothyroxine be taken?

A

empty stomach

17
Q

What to be cautious about levothyroxine?

A

narrow therapeutic index so easy to make hyperthyroid or hypothyroid

18
Q

How long does levothyroxine take to work?

A

4-6wks

19
Q

ADR for aspart and lispro? Same as?

A

lipodystrophy
wt gain
same as reg insulin and glargine

20
Q

ADR for Repaglinide?

A

CV risk
tolerance
SIADH

21
Q

What antihyperglycemic has NO hypoglycemia?

A

biguanide/metformin

acarbose

22
Q

ADR for metformin?

A

lactic acidosis

23
Q

Who to avoid metformin in?

A

do not give to pts >80yo
GI prob
vitamine B12 def

24
Q

ADR for exentaide?

A

acut epancreatitis

25
Q

DI for exentaide?

A

warfarin

digoxin

26
Q

ADR for acarbose?

A

flatulence and diarrhea

monitor LFT for liver toxicity

27
Q

ADR for pioglitazone?

A

hepatoxicity -omnitor LFT

wt gain

28
Q

ADR for orlistat/

A

vitamin A D E K def

29
Q

DI for orlistat?

A

vitamin K

warfarin

WHOLE PT (19 decks)

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