Hemolymphatics Part 2 Flashcards

1
Q

location of T cells:
location of B cells:
location of macrophages, lymphocytes, plasma cells:

A

paracortex
cortex/germinal center
medulla

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2
Q

what disease:
chronic GI signs - diarrhea
fluid accumulation
dilated lymphatics
most common cause of PLE
peripheral edema, ascites, hydrothorax

A

intestinal/enteric lymphangiectasia

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3
Q

what disease:
chronic GI signs
inflam foreign body reaction
granulomatous inflam forming white masses on serosal/mucosal surfaces

A

intestinal lipogranulomatous lymphangitis

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4
Q

4 findings of PLE

A

hypoproteinemia
hypocholesterolemia
lymphopenia
hypocalcemia

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5
Q

4 causes of chylothorax

A

idiopathic (most common)
Trauma
congestive heart failure (cats>dogs)
chest tumors

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6
Q

List 5 viruses that can injure lymphoid tissue

A

Parvovirus
Canine distemper virus
FIV
EHV-1
BVDV

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7
Q

how is plague spread and what is the gross finding in cats with plague

A

Bubonic – rodent/fleas
Septicemic – skin breakage
Pneumonic – air droplets

Peripheral lymphadenopathy

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8
Q

Name 2 causes of bacterial lymphadenitis in horses

A

Streptococcus equi equi “strangles”
Rhodococcus equi

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9
Q

List 3 bacterial causes of bacterial lymphadenitis in cattle or sheep

A

Mycobacterium avium paratuberculosis
Mycobacterium bovis
Corynebacterium pseudotuberculosis

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10
Q

what bacteria:
enteritis and granulomatous lymphadenitis
chronic, proliferative enteritis
aggregates of epithelioid macrophages and multinucleated giant cells
sheep/goat often get granulomas with necrotic caseous centers & mineralization

A

Mycobacterium avium paratuberculosis
“Johne’s disease”

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11
Q

what bacteria:
LN are necrotic & suppurative/abscessed, chronic progressive disease
spread to humans via raw milk or milk products

A

Mycobacterium bovis
“bovine TB”

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12
Q

what bacteria:
purulent to inspissated with concentric laminations, can cause internal abscessation and chronic wasting
horizontal transmission

A

Corynebacterium pseudotuberculosis

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13
Q

what virus causes thymic atrophy and granulomatous inflammation

A

PCV-2

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14
Q

what virus causes lymphoid depletion with granulomatous inflam with multinucleated giant cells and cytoplasmic viral inclusion bodies

A

PCV-2

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15
Q

List 5 characteristics that define types of lymphoma

A
  1. anatomic location
  2. cell origin
  3. cell morphology
  4. histologic pattern
  5. biologic behavior
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16
Q

clinical signs associated with lymphoma

A

generalized lymphadenomegaly
GI (thickened intestine, hepatomegaly, splenomegaly)
mild-mod non-reg anemia
lymphopenia/lymphocytosis
hypercalcemia
hyperglobulinemia

17
Q

flow cytometry
pros:
cons:

A

pros: subtype & prognosis
cons: fresh viable sample and need sig neoplastic population

18
Q

histopathology
pros:
cons:

A

pros: subtype & prognosis with IHC
cons: requires IHC

19
Q

what techniques can be used on cytology, histology or non-viable samples?

A

PCR
PARR

20
Q

PCR
pros:
cons:

A

pros: can be performed on cytology, histology, non-viable samples
cons: diagnosis not prognosis

21
Q

PARR
pros:
cons:

A

pros: distinguish between neoplasia and reactive/hyperplasia, can use cytology, histology or non-viable samples
cons: NOT prognostic

22
Q

In cats, list 2 prognostic features in GI lymphoma

A
  1. Transmural (poor prognosis) or mucosal (good prognosis)
  2. Stomach & large intestine (poor prognosis) or small intestine (good prognosis)
  3. Cell size - large (poor) & small (good)
  4. T vs B cell
23
Q

Name the disease that is typically associated with thymic lymphoma in cats

A

FELV/FIV

24
Q

List two viruses associated with lymphoma in chickens and the difference in anatomic distribution in these diseases

A
  1. Gallid herpesvirus 2 “Marek’s disease” - enlarged peripheral nerves and diffuse/nodular lymphoid tumors in heart, ovary, liver, lung, kidney, eyes, feathers, CNS
  2. lymphoid leukosis - bursa and lymphoid tumors
25
Q

how is Marek’s disease spread

A

bird-bird or contaminated soil, clothes, equipment, dust/dander, aerosol

26
Q

characteristics of BLV

A

retrovirus
adult dairy cattle
persistent lymphocytosis
heart, uterus, LN, abomasum (HULA)

27
Q

characteristics of sporadic lymphoma in cattle
what are the three syndromes?

A

younger animals
3 syndromes - thymic, multicentric, cutaneous

28
Q

Name 4 common sites of disease in BLV associated lymphoma

A

heart
uterus
LN
abomasum

29
Q

List 3 disease syndromes in sporadic lymphoma in cattle

A

Thymic disease – < 2 yrs, resp distress
Multicentric disease – 3-6 mo, liver, spleen, kidney, BM involvement
Cutaneous – 1-3 yrs, plaques