Hemoglobin and Oxygen Delivery

Question 1

Hemoglobin composition

Answer 1

2 alpha-globin chains, 2 beta-globin chains, each globin chain with a heme group that contains iron and reversibly binds O2

Question 2

best definition of anemia

Answer 2

low hemoglobin

Question 3

conjunctival pallor

Answer 3

definite sign of low hemoglobin, no red region of conjunctiva

Question 4

myoglobin

Answer 4

monomeric heme-containing O2 binding protein

Question 5

Hemoglobin A

Answer 5

major hemoglobin in adults

Question 6

changes in hemoglobin with oxygenation

Answer 6

chains within each dimer are held tightly together by hydrophobic interactions

Question 7

deoxyhemoglobin

Answer 7

T or taut structure; low oxygen affinity - ionic and H bonds constrain movement of polypeptide chains

Question 8

oxyhemoglobin

Answer 8

R or relaxed structure; high oxygen-affinigy form of Hb, binding of O2 to Hb causes rupture of some polar bonds between the alpha-beta dimers allowing movement