Hemoglobin

Question 1

Hemoglobin

Answer 1

Enables our blood to carry ~60-70 times more O2, has 200 times more affinity for CO than O2

Question 2

RBC

Answer 2

Contains approximately 300mill molecules of hemoglobin

Question 3

HbS

Answer 3

Sickle Cell anemia, has one amino acid different from a normal adult (HbA)

Question 4

Vertical Hemoglobin

Answer 4

Has 4 subunits, each with a heme group, heme part contains fe++ which binds one oxygen

Question 5

HbS Symptoms

Answer 5

Causes Hb to polymerize and crystalize producing RBC rigidity and obstruction of capillaries, usually during low oxygen

Question 6

Bohr Effect

Answer 6

Hemoglobin loads more O2 in lungs where pH is high and unloads more in tissue where pH is low

Question 7

Normal Arterial pH

Answer 7

7.4

Question 8

pH changes

Answer 8

Strongly affect binding of O2 to hemoglobin

Question 9

Basic pH

Answer 9

More oxygen

Question 10

Acidic pH

Answer 10

Less oxygen, during exercise

Question 11

Exercise pH levels

Answer 11

During exercise pH can fall to 6.9 in muscle capillaries, this increases O2 unloading by Bohr Effect

Question 12

HbF

Answer 12

Fetal hemoglobin, has higher affinity for O2 than HbA in order to extract O2 from mom, switched to HbA at birth

Question 13

Sickle-Cell Anemia

Answer 13

Curve is shifted right