HEMOGLOBIN Flashcards
OCCURS WHEN HEMOGLOBIN BREAKS DOWN IN THE BLOD AND FREE HEMOGLOBIN RELEASED INTO PLASMA
INTRAVASCULAR HEMOLYSIS
OCCURS WHEN SENESCENT/OLD RBC ARE PHAGOCYTIZED BY MACROPHAGES IN THE LIVER OR SPLEEN.
EXTRAVASCULAR HEMOLYSIS
MEASURES THE AMOUNT OF FE +3 BOUND TO TRANSFERRIN
SERUM IRON
MEASURE THET TOTAL AMOUNT OF IRON THAT TRANSFERRIN CAN BIND WHEN FULLY SATURATED
TIBC
INDIRECT MEASUREMENT OF STORAGE IRON IN TISSUE AND BONE MARROW
SERUM FERRITIN
Hgb F CONTAINS
TWO ALPHA 2. GAMMA GLOBIN CHAIN
A COMPENSATIRY HGB AND CAN BE INCREASED IN HOMOZYGOUS HEMOGLOBINOPATHIES AND BETA THALLASEMIA MAJOR.
HGB F
HGB A CONTAINS
2 ALPHA
2 BETA GLOBULIN CHAIN
HGB A2 CONTAINS
2 ALPHA 2 DELTA GLOBIN CHAIN
HEMOGLOBIN FE 2+ and O2 seen in arterial circulation
Oxyhemoglobin
Hemoglobin Fe 2+ and no O2 seen in venous circulation
Deoxyhemoglobin
Hemoglobin Fe 2+ and carbon monoxide that has 200x more affinity for CP than O2
Carboxyhemoglobin
Hemoglobin with S cannot transport O2 and seldom reaches fatal levels
Sulfhemoglobin
Hemoglobin with FE 3+ cannot transport O2
Methemoglobin
choose Left shift or right shift
Decrease oxygen affinity and body pH
Increased O2 release, 2,3 BPG and body temp
RIGHT SHIFT