ERYTHROCYTE Flashcards
WHAT IS THE NORMAL LIFE SPAN OF RBC?
120 DAYS
WHERE DOES THE ERYTHROPOIETIN PRODUCES?
KIDNEY
THIS STAIN USED TO ENUMERATE RETICULOCYTE
SUPRAVITAL STAIN
ONE OF THE BEST INDICATORS OF BONE MARROW FUNCTION
RETICULOCYTE COUNT
A YOUNG CELLS RELEASED FROM BONE MARRW AFTER OLDER RETICULOCYTES HAVE BEEN RELEASED. THIS IS A RESPONSE TO INCREASED NEED..
STRESS RETICULOCYTE
NORMAL CELL HAVE A CENTRAL PALLOR THAT IS ____
ONE THIRD
DECREASED CENTRAL PALLOR IS SEEN WITH
SPHEROCYTIC DISORDER INCLUDING THERMAL INJURY AND LIVER DISEASE.
CENTRAL PALLOR GREATER THAN THE NORMAL SIZE IS SEEN IN
MACROCYTIC ANEMIA
REFERENCE RANGE OF RBC IN WOMEN
MEN
FEMALES: 4.0-5.4
MALE: 4.6-6.0
ERYTHROPOIESIS IS REGULATED BY:
ERYTHROPOIETIN
WHAT ARE THE OTHER REGULATIONS IN RBH INCLUDES:
HYPOXIA DUE TO HIGH ALTITUDES, HEART OR LUNG DYSFUNCTION, ANEMIA
ANDROGENS AND HEMOLYTIC ANEMIA
WHAT ARE THE SUBSTANCES NEEDED FOR ERYTHROPOIESIS
IRON
AMIINO ACID
FOLIC ACID./ VIT. B12
OTHERS: ERYTHROPOIETIN , VIT B6, TRACE MINERALS
EVENLY SPACED ROUND PROJECTIONS , CENTRAL PALLOR ARE PRESENT
ECHINOCYTES INCLUDE BURR CELL AND CRENATED
UNEVENLY SPACED POINTED PROJECTIONS AND LACK OF CENTRAL PALLOR
ACANTHOCYTES
SHOWS A CENTRAL AREA OF HEMOGLOBIN SURROUNDED BY A COLORLESS RING AND A PERIPHERAL RING OF HEMOGLOBIN
CELLS AHVE A INCREASED SURFACE TO VOLUME RATIO
TARGET CELL
DISC SHAPED CELL WITH A SMALLER VOLUME THAN A NORMAL ERYTHROCYTE, CELLS HAVE A DECREASED SURFACE TO VOLUME RATIO
SPHREOCYTE
PEARED SHAPE WITH ONE BLUNT PROJECTION
TEARDROPS (DACROCYTE)
SHAPES VARY BUT SHOW THIN, ELONGATED, POINTED ENDS AND WILL APPEAR CRESCENT SHAPED USUALLY LACK OF CENTRAL PALLOR
SICKLE CELLS
INTERIOR PORTION OF CELL IS HOLLOW, RESEMBLING A HORN OR HELMET
HELMET CELLS
DAMAGED RBC, FRAGMENTS OF VARIOUS SIZES AND SHAPES ARE PRESENT OFTEN WITH POINTED PROJECTIONS
SCHISTOCYTES
CHARACTERIZEDBY AN ELONGATED OR SLIT-LIKE AREA OF CENTRAL PALLOR
STOMATOCYTE
CIGAR TO EGG SHAPED RBC
ELLIPTOCYTE
WHAT DISEASES CAN A ECHINOCYTES PRESENT?
LIVER DISEASE
UREMIA
HEPARIN THERAPY
PYRUVATE KINASE DEFICIENCY
WHAT DISEASES CAN A ACHANTOCYTE PRESENT?
ALCOHOLIC LIVER DISEASE
POST SPLENECTOMY
ABETALIPOPROTEINEMIA
WHAT DISEASES CAN A TARGET CELL PRESENT?
LIVER DISEASE, HEMOGLOBINOPATHIES, THALASSEMIA, IDA,
WHAT DISEASES CAN A SPHEROCYTES PRESENT?
DAMAGED RBC: G6PD DEFICIENCY, HEREDITARY SPHEROCYTOSIS, IMMUNE HEMOLYTIC ANEMIA
MICROSPHEROCYTES: SEVERE THERMAL INJURY
WHAT DISEASES CAN A TEARDROP CELLS PRESENT?
MEGALOBLASTIC ANEMIA
THALASSEMIA
EXTRAMEDULLARY HEMATOPOIESIS
WHAT DISEASES CAN A SICKLE CELL PRESENT?
HEMOGLBINOPATHIES SS, SC, SD
WHAT DISEASES CAN A HELMET CELLS PRESENT?
MICROANGIOPATHIC HEMOLYTIC ANEMIA
WHAT DISEASES CAN A SCHISTOCYTE PRESENT?
Microangiopathic HEMOLYTIC ANEMIA, G6PD DEFICIENCY, THERMAL INJURY, RENAL TRANSPLANT REJECTION.
WHAT DISEASES CAN A STOMATO CYTES PRESENT?
LIVER DISEASE, HEREDITARY STOMATOCYTOSIS OR AN ARTIFACT
WHAT DISEASES CAN A ELLIPTOCYTES PRESENT?
HEREDITARY ELLIPTOCYTOSIS, IDA, MEGALOBALSTIC ANEMIA, THALASSEMIA MAJOR.
THE NRBCS AR USUALLY APPEAR IN
ORTHOCHROMIC NORMOBLASTS
THIS RBC INCLUSIONS INDICATE BONE MARROW STIMULATION OR INCREASED ERYTHROPOIESIS
NUCLEATED RBC
SMALL, ROUND DNA FRAGMENT USUALLY ONE PER CELL, BUT CAN BE MULTIPLE STAIN DARK PURPLE TO BLACK IN WRGHT STAIN
HOWELL JOLLY BODIES
HOWELL - JOLLY BODIES IS SEEN
SICKLE CELL ANEMIA, BETA THALASSEMIA MJOR, OTHER SEVERE HEMOLYTIC ANEMIA, MEGALOBLASTIC ANEMIA, ALCOHOLISM POST SPLENECTOMY.
COARSE INCLUSION (RIBOSOMAL RNA REMNANTS)
BASOPHILIC STIPPLING
BASOPHILIC STIPPLING IS SEEN IN
THALASSEMIAS, MEGALOBLASTIC ANEMIA, SIDEROBLASTIC ANEMIA, LEAD POISONING, AND ALCOHOLISM
DARK STAINING IRON GRANULES USUALLY CLUMPED TOGETHER AT PERIPHERY OF THE CELL
PAPPENHEIMER BODIES
WHAT STAIN IS SED IN PAPPENHEIMER BODIES?
PERL’S PRUSSIAN BLUE STAIN
PAPPENHEIMER BODIES IS SEEN IN
SIDEROBLASTIC ANEMIA, HEMOGLOBINOPATHIES, THALASSEMIA
MEGALOBLASTIC ANEMIA
MYELODYSPLASTIC SYNDROME RARS
THIN, RED VIOLET. SINGLE TO MULTIPLE RINGLIKE STRUCTURES THAT MAY APPEAR IN LOOP OR FIGURE OF EIGHT SHAPES
CABOT RINGS
CABOT RINGS ARE SEEN IN
MEGALOBLASTIC ANEMIA, MYELODYSPLASTIC SYNDROME, LEAD POISONING
ROD SHAPE CRYSTAL
HEMOGLOBIN C
ONE TO TWO BLUNT, FINGERLIKE PROJECTIONS EXTENDING FROM THE CELL MEMBRANE.
WASHINGTON MONUMENT
HEMOGLOBIN SC
INVISIBLE WITH WRIGHT STAIN
REPRESENTS DENATURED HEMOGLOBIN
HEINZ BODIES
HEINZ BODIES IS SEEN IN
G6PD DEFICIENCY
BETA-THALASSEMIA MAJOR
HGB H DISEASE
UNSTABLE HEMOGLOBINPATHIES
DRUG INDUCED ANEMIAS
MCH AND MCHC IS DECREASED
CENTRAL PALLOR IS GRATER THAN 1/3 OF THE DIAMETER
HYPOCHROMASIA
HYPOCHROMASIA IS SEEN IN
IDA, THALASSEMIA, ANEMIA OF CHRONIC DISEASE, SIDEROBLASTIC ANEMIA, MYELODYSPLATIC SYNDROME
VARIATION IN HGB CONTENT SHOWING A SLIGHT BLUE TIGER WHEN STAINED WITH WRIGHT STAIN; RESIDUAL RNA
POLYCHROMASIA
STACKING OF COIN PATTER OF RBC DUE TO
ABNORMAL OR INCREASED PLASMA PROTEINS
STACKING OF COIN
ROULEAUX
TRUE ROULEAX FORMATION IS SEEN IN
THIN AREA F THE PERIPHERAL SMEAR
AN ROULEAUX THAT CONSIDER ARTIFACT IS SEEN IN
THICKER AREA OF THE PERIPHERAL SMEAR
CHARACTERIZED BY CLUMPING OF RBC WITH NO PATTERN.
AGGLUTINATION
AGGLUTINATION OCCURS
RBC ARE COATED WITH IGM ANTIBODIES AND COMPLEMENT
AGGLUTINATION SEEN IN
COLD AUTOIMMUNE HEMOLYTIC ANEMIA
WHAT IS THE REMEDY FOR THE AGGLUTINATION
WARM BLOOD AT 37C TO CORRECT A FALSE LOW RBC AND HCT AND FALSE HIGH MCHC
