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HEMATOLOGY 1 > ERYTHROCYTE > Flashcards

ERYTHROCYTE Flashcards

1
Q

WHAT IS THE NORMAL LIFE SPAN OF RBC?

A

120 DAYS

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2
Q

WHERE DOES THE ERYTHROPOIETIN PRODUCES?

A

KIDNEY

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3
Q

THIS STAIN USED TO ENUMERATE RETICULOCYTE

A

SUPRAVITAL STAIN

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4
Q

ONE OF THE BEST INDICATORS OF BONE MARROW FUNCTION

A

RETICULOCYTE COUNT

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5
Q

A YOUNG CELLS RELEASED FROM BONE MARRW AFTER OLDER RETICULOCYTES HAVE BEEN RELEASED. THIS IS A RESPONSE TO INCREASED NEED..

A

STRESS RETICULOCYTE

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6
Q

NORMAL CELL HAVE A CENTRAL PALLOR THAT IS ____

A

ONE THIRD

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7
Q

DECREASED CENTRAL PALLOR IS SEEN WITH

A

SPHEROCYTIC DISORDER INCLUDING THERMAL INJURY AND LIVER DISEASE.

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8
Q

CENTRAL PALLOR GREATER THAN THE NORMAL SIZE IS SEEN IN

A

MACROCYTIC ANEMIA

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9
Q

REFERENCE RANGE OF RBC IN WOMEN
MEN

A

FEMALES: 4.0-5.4
MALE: 4.6-6.0

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10
Q

ERYTHROPOIESIS IS REGULATED BY:

A

ERYTHROPOIETIN

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11
Q

WHAT ARE THE OTHER REGULATIONS IN RBH INCLUDES:

A

HYPOXIA DUE TO HIGH ALTITUDES, HEART OR LUNG DYSFUNCTION, ANEMIA
ANDROGENS AND HEMOLYTIC ANEMIA

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12
Q

WHAT ARE THE SUBSTANCES NEEDED FOR ERYTHROPOIESIS

A

IRON
AMIINO ACID
FOLIC ACID./ VIT. B12
OTHERS: ERYTHROPOIETIN , VIT B6, TRACE MINERALS

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13
Q

EVENLY SPACED ROUND PROJECTIONS , CENTRAL PALLOR ARE PRESENT

A

ECHINOCYTES INCLUDE BURR CELL AND CRENATED

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14
Q

UNEVENLY SPACED POINTED PROJECTIONS AND LACK OF CENTRAL PALLOR

A

ACANTHOCYTES

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15
Q

SHOWS A CENTRAL AREA OF HEMOGLOBIN SURROUNDED BY A COLORLESS RING AND A PERIPHERAL RING OF HEMOGLOBIN
CELLS AHVE A INCREASED SURFACE TO VOLUME RATIO

A

TARGET CELL

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16
Q

DISC SHAPED CELL WITH A SMALLER VOLUME THAN A NORMAL ERYTHROCYTE, CELLS HAVE A DECREASED SURFACE TO VOLUME RATIO

A

SPHREOCYTE

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17
Q

PEARED SHAPE WITH ONE BLUNT PROJECTION

A

TEARDROPS (DACROCYTE)

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18
Q

SHAPES VARY BUT SHOW THIN, ELONGATED, POINTED ENDS AND WILL APPEAR CRESCENT SHAPED USUALLY LACK OF CENTRAL PALLOR

A

SICKLE CELLS

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19
Q

INTERIOR PORTION OF CELL IS HOLLOW, RESEMBLING A HORN OR HELMET

A

HELMET CELLS

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20
Q

DAMAGED RBC, FRAGMENTS OF VARIOUS SIZES AND SHAPES ARE PRESENT OFTEN WITH POINTED PROJECTIONS

A

SCHISTOCYTES

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21
Q

CHARACTERIZEDBY AN ELONGATED OR SLIT-LIKE AREA OF CENTRAL PALLOR

A

STOMATOCYTE

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22
Q

CIGAR TO EGG SHAPED RBC

A

ELLIPTOCYTE

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23
Q

WHAT DISEASES CAN A ECHINOCYTES PRESENT?

A

LIVER DISEASE
UREMIA
HEPARIN THERAPY
PYRUVATE KINASE DEFICIENCY

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24
Q

WHAT DISEASES CAN A ACHANTOCYTE PRESENT?

A

ALCOHOLIC LIVER DISEASE
POST SPLENECTOMY
ABETALIPOPROTEINEMIA

25
Q

WHAT DISEASES CAN A TARGET CELL PRESENT?

A

LIVER DISEASE, HEMOGLOBINOPATHIES, THALASSEMIA, IDA,

26
Q

WHAT DISEASES CAN A SPHEROCYTES PRESENT?

A

DAMAGED RBC: G6PD DEFICIENCY, HEREDITARY SPHEROCYTOSIS, IMMUNE HEMOLYTIC ANEMIA
MICROSPHEROCYTES: SEVERE THERMAL INJURY

27
Q

WHAT DISEASES CAN A TEARDROP CELLS PRESENT?

A

MEGALOBLASTIC ANEMIA
THALASSEMIA
EXTRAMEDULLARY HEMATOPOIESIS

28
Q

WHAT DISEASES CAN A SICKLE CELL PRESENT?

A

HEMOGLBINOPATHIES SS, SC, SD

29
Q

WHAT DISEASES CAN A HELMET CELLS PRESENT?

A

MICROANGIOPATHIC HEMOLYTIC ANEMIA

30
Q

WHAT DISEASES CAN A SCHISTOCYTE PRESENT?

A

Microangiopathic HEMOLYTIC ANEMIA, G6PD DEFICIENCY, THERMAL INJURY, RENAL TRANSPLANT REJECTION.

31
Q

WHAT DISEASES CAN A STOMATO CYTES PRESENT?

A

LIVER DISEASE, HEREDITARY STOMATOCYTOSIS OR AN ARTIFACT

32
Q

WHAT DISEASES CAN A ELLIPTOCYTES PRESENT?

A

HEREDITARY ELLIPTOCYTOSIS, IDA, MEGALOBALSTIC ANEMIA, THALASSEMIA MAJOR.

33
Q

THE NRBCS AR USUALLY APPEAR IN

A

ORTHOCHROMIC NORMOBLASTS

34
Q

THIS RBC INCLUSIONS INDICATE BONE MARROW STIMULATION OR INCREASED ERYTHROPOIESIS

A

NUCLEATED RBC

35
Q

SMALL, ROUND DNA FRAGMENT USUALLY ONE PER CELL, BUT CAN BE MULTIPLE STAIN DARK PURPLE TO BLACK IN WRGHT STAIN

A

HOWELL JOLLY BODIES

36
Q

HOWELL - JOLLY BODIES IS SEEN

A

SICKLE CELL ANEMIA, BETA THALASSEMIA MJOR, OTHER SEVERE HEMOLYTIC ANEMIA, MEGALOBLASTIC ANEMIA, ALCOHOLISM POST SPLENECTOMY.

37
Q

COARSE INCLUSION (RIBOSOMAL RNA REMNANTS)

A

BASOPHILIC STIPPLING

38
Q

BASOPHILIC STIPPLING IS SEEN IN

A

THALASSEMIAS, MEGALOBLASTIC ANEMIA, SIDEROBLASTIC ANEMIA, LEAD POISONING, AND ALCOHOLISM

39
Q

DARK STAINING IRON GRANULES USUALLY CLUMPED TOGETHER AT PERIPHERY OF THE CELL

A

PAPPENHEIMER BODIES

40
Q

WHAT STAIN IS SED IN PAPPENHEIMER BODIES?

A

PERL’S PRUSSIAN BLUE STAIN

41
Q

PAPPENHEIMER BODIES IS SEEN IN

A

SIDEROBLASTIC ANEMIA, HEMOGLOBINOPATHIES, THALASSEMIA
MEGALOBLASTIC ANEMIA
MYELODYSPLASTIC SYNDROME RARS

42
Q

THIN, RED VIOLET. SINGLE TO MULTIPLE RINGLIKE STRUCTURES THAT MAY APPEAR IN LOOP OR FIGURE OF EIGHT SHAPES

A

CABOT RINGS

43
Q

CABOT RINGS ARE SEEN IN

A

MEGALOBLASTIC ANEMIA, MYELODYSPLASTIC SYNDROME, LEAD POISONING

44
Q

ROD SHAPE CRYSTAL

A

HEMOGLOBIN C

45
Q

ONE TO TWO BLUNT, FINGERLIKE PROJECTIONS EXTENDING FROM THE CELL MEMBRANE.
WASHINGTON MONUMENT

A

HEMOGLOBIN SC

46
Q

INVISIBLE WITH WRIGHT STAIN
REPRESENTS DENATURED HEMOGLOBIN

A

HEINZ BODIES

47
Q

HEINZ BODIES IS SEEN IN

A

G6PD DEFICIENCY
BETA-THALASSEMIA MAJOR
HGB H DISEASE
UNSTABLE HEMOGLOBINPATHIES
DRUG INDUCED ANEMIAS

48
Q

MCH AND MCHC IS DECREASED
CENTRAL PALLOR IS GRATER THAN 1/3 OF THE DIAMETER

A

HYPOCHROMASIA

49
Q

HYPOCHROMASIA IS SEEN IN

A

IDA, THALASSEMIA, ANEMIA OF CHRONIC DISEASE, SIDEROBLASTIC ANEMIA, MYELODYSPLATIC SYNDROME

50
Q

VARIATION IN HGB CONTENT SHOWING A SLIGHT BLUE TIGER WHEN STAINED WITH WRIGHT STAIN; RESIDUAL RNA

A

POLYCHROMASIA

51
Q

STACKING OF COIN PATTER OF RBC DUE TO

A

ABNORMAL OR INCREASED PLASMA PROTEINS

52
Q

STACKING OF COIN

A

ROULEAUX

53
Q

TRUE ROULEAX FORMATION IS SEEN IN

A

THIN AREA F THE PERIPHERAL SMEAR

54
Q

AN ROULEAUX THAT CONSIDER ARTIFACT IS SEEN IN

A

THICKER AREA OF THE PERIPHERAL SMEAR

55
Q

CHARACTERIZED BY CLUMPING OF RBC WITH NO PATTERN.

A

AGGLUTINATION

56
Q

AGGLUTINATION OCCURS

A

RBC ARE COATED WITH IGM ANTIBODIES AND COMPLEMENT

57
Q

AGGLUTINATION SEEN IN

A

COLD AUTOIMMUNE HEMOLYTIC ANEMIA

58
Q

WHAT IS THE REMEDY FOR THE AGGLUTINATION

A

WARM BLOOD AT 37C TO CORRECT A FALSE LOW RBC AND HCT AND FALSE HIGH MCHC

HEMATOLOGY 1 (8 decks)

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