erythrpocyte Flashcards
aerobically converts glucose to pentose and produces NADPH
hexose mnophosphate shunt
most common enzyme deficiency in the pentose phosphate pathway
G6PD DEFICIENCY
RECOMMENDED SCREENING TEST FOR G6PD DEFICIENCY
G6PD FLUORESCENT SPOT TEST
A SCREENING TEST FOR 6G6D DEFICIENCY WHERE THE PATTERN IS SLIGHTLY TO MODERATE INCREASED BUT IS PARTIALLY CORRECTED BY GLUCOSE
AUTOHEMOLYSIS
CLAASIFICATION OF G6PD SEVERELY DEFICIENT
CLINICAL MANIFESTATION: HNSHA
VARIANTS: G6PD - SERRES AND G6PD MADRID
CLASS 1
CLAASIFICATION OF G6PD SEVERELY DEFICIENT
CLINICAL MANIFESTATION ASSOCIATED WITH FAVA BEANS AND FAVISM AND AY REQUIRED TRANSFUSION DURING HEMOLYTIC EPISODES
VARIANTS G6PD: MEDITERRANEAN
G6PD: CHATAM
CLASS 2
CLAASIFICATION OF G6PD MODERATELY TO MILDLY DEFICIENT
CLINICAL MANIFESTATION: SELF LIMITED, EPISODIC
VARIANTS:G6PD A AND G6PD CANTON
CLASS 3
CLAASIFICATION OF G6PD MILDLY DEFICIENT
CLINICAL MANIFESTATION NONE
VARIANTS: G6PD B AND G6PD A THAT MAY ALSO MANIFEST CLASS 3
CLASS 4
CLAASIFICATION OF G6PD INCREASED ACTIVITY
CLINICAL MANIFESTATION NONE
VARIANTS NONE
CLASS 5
MAINTAINS IRON IN THE HEME IN ITS REDUCED STATE
METHEMOGLOBIN REDUCTASE PATHWAY
FOR THE PRODUCTION OF 2,3- BPG
RAPOPORT-LEIEBERING SHUNT
THE CURVE WHEN THE 2 VARIABLES ( PARTIAL PRESSURE OF OXYGEN AND AFFINIY OF HB0 ARE PLOTTED ON TEH GRAPH
OXYGEN DISSOCIATION CURVE
A SHIFT IN TEH CURVE DUE TO ALTERATION IN PH
EFFECT OF HYDROGEN INS AND CO2 ON TEH AFFINITY OF HEMOGLOBIN FOR OXYGEN
BOHR EFFECT
DEPICTS THE OCCURRENCE BY WHICH THE BINDING OF O2 TO THE HB PROMOTES THE RELEASE OF CO2
HALDANE EFFECT
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INCREASED PH
DECREASED PCO2
DECREASED 2,3-BPG
DECREASED TEMPERATURE
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V SHIFT TO THE LEFT OR SHIFT TO THE RIGHT
INCREASED PH
DECREASED PCO2
DECREASED 2,3-BPG
DECREASED TEMPERATURE
WHAT IS THE AFFINITU?
INCREASED
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DECREASED PH
INCREASED PCO2
INCREASED 2,3-BPG
INCREASED TEMPERATURE
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SHIFT TO THE LEFT OR SHIFT TO THE RIGHT
DECREASED PH
INCREASED PCO2
INCREASED 2,3-BPG
INCREASED TEMPERATURE
WHAT IS THE AFFINITY
DECREASED
INCREASED NUMBER OF RED CELLS WITH VARIATION IN SIZE
ANISOCYTOSIS
LARGER THAN NORMAL RBC.
USUALLY SEEN WHEN NCV IS GREATER THAN 100
ASSOCIATED WITH IMPAIRED DNA
MACROCYTES
SMALLER THAN NORMAL
USUALLY SEEN WHEN THE MCV IS <80 FL
ASSOCIATED WITH DEFECTIVE HEMOGLOBIN FORMATION
MICROCYTES
BLOOD CELL HISTOGRAM THE X AXIS IS FOR:
CELLS SIZE
BLOOD CELL HISTOGRAM THE Y AXIS IS FOR
NUMBER OF CELLS
TWO PARAMETERS CALCULATED FRIM RBC HISTOGRAM
MCV AND RDW
IF THE RBC ARE MICROCYTES TE CURVE WILL SHIFT TO
RIGHT
IF THE RBCS ARE MACROCYTIC THE CURVE WILL SHIFT. TO THE
LEFT
IF THE HISTOGRAM CURVE IS BIMDAL THEN THERE ARE
TWO POPULATION OF RBC IN THE SAMPLE
WHAT CAN CAUSE BIMODAL DISTRIBUTION
BLOOD TRANSFUSION
COLD AGGLUTINATION
HEMOLYTIC ANEMIA WITH SCHISTOCYTE PRESENT
A CALCULATED INDEX GIVEN BY HEMATOLOGY ANALYZERS TO HELP IDENTIFY ANISOCYTOSIS AND PROVIDE INFORMATION ABOUT ITS DEGREE
RED CELL DISTRIBUTION WIDTH
BASED IN BITH THE WIDTH OF THHE RBC DISTRIBUTION CURVE AND THE MEAN RBC SIZE
DEPENDENT BY WIDTH AND MCV
RDW-CV
THE ACTUAL MEASUREMENT OF THE WIDTH OF THE RBC DISTRIBUTION CURVE IN FL
NOT INCLUENCED BY MCV
RDW SD
BETTER AND MOST RELIABLE MEASURE OF RBC VARIABILITY SPECIFICALLY IN HIGH ABNORMAL CONDITIONS
RDW-SD
WHEN WILL BE THE RDW DECREASE IN NEWBORNS
6 MOS OF AGE
VARIATION IN THE NORMAL COLOR
ANISOCHROMIA
OCCURRENCE OF HYPOCHROMIC CELLS AND NORMOCHROMIC CELLS IN THE BLOOD SMEAR
ANISOCHROMIA
ANISOCHROMIA CAN BE SEEN IN
SIDEROBALSTIC ANEMIA
HYPOCHROMIA AFTER TRANSFUSION WITH NORMAL CELLS
WEEKS AFTER IRON THERAPY FOR IDA
GRADING OF HYPOCHROMIA
1+ AREA OF CENTRAL PALLOR = 1/2 DIAMETER
2+ AREA OF CENTRAL PALLOR = 2/3
3+ AREA OF CENTRAL PALLOR = 3/4
4+ AREA OF CENTRAL PALLOR = THIN RIM OF HB
BC WITH A THIN RIM OF HEMOGLOBIN AND A LARGE CLEAR CENTER
ANULOCYTE/ PESSARY CELL OR GHOST CELL
ANULOCYTE MGHT BE SEEN IN
IRON DEFICIENCY ANEMAI
BASICALLY THE ONLY DISEASE IN WHICH THE MCHC IS HIGH
HHEREDITARY SPHEROCYTOSIS
HS HAS 3 KEY CLINCIAL MANIFESTATION
SPLEENOMEGALY
ANEMIA
JAUNDICE
LAB RESULT OF PX WITH HS
DAT- NEGATIVE
MCV NORMAL TO LOW
MCH- NORMAL
MCHC SLIGHTLY INCREASED
CONFIRMATORY TEST FOR HS DISEAE
EMA BINDING TEST
LARGER THAN NORMAL RED CELL WITH BLUISH TINGE
PLOYCHROMATOPHILIC ERYTHROCYTES
BLUISH TINGE IN POLYCHROMATOPHILIC ERYTHROCYTE IS CAUSED BY
THE PRESENCE OF RESIDUAL RNA
LARGE UMBER OF POLYCHROMATOPHILIC ERYTHROCYTE CAN BE FOUND IN
DECREASED RBC SURVIVAL
HEMORRHAGE
ERYTHROID HYPERPLASTIC MARROW
EARLIEST METHOD PROVIDED BY THE HEMATOOLOGY ANALYZER TO EMASURE RED CELL VARIATION
RDW-CV
WHAT CONDITION HAS THIS DECREASED MCV AND LITTLE OR NO ANISOCYTOSIS
ANEMIA OF CHRONIC INFECTION
WHAT CONDITION HAS THIS DECREASED MCV AND INCREASED ANISOCYTOSIS
IDA
