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HEMATOLOGY 1 > erythropoiesis > Flashcards

erythropoiesis Flashcards

1
Q

process of RBC FORMATION TAKESS PLACE INSIDE THEE BONE MARROW

A

ERYTHROPOIESIS

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2
Q

TOTAL MASS OF RBCS CIRCULATING IN THE PERIPHERAL BLOOD ADN THE BONE MARROW RBC PRECURSOR

A

ERYTHRON

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3
Q

ERYTHROCYTES IN THE CIRCULATION

A

RBC MASS

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4
Q

A TERM THAT DESCRIBE THE DYNAMICS OF RBC CREATION AND DESTRUCTION

A

ERYTHROKINETICS

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5
Q

PRODUCTION OF DEFEECTIVE ERYTHROID PRECUSOR

A

INFFECTIVE ERYTHROPOIESIS

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6
Q

EXAMPLES OF CONDITIONS OF INEFFECTIVE ERYTHROPOIESIS

A

VITAMIN B12 DEFICIENCY
FOLATE DEFICIENCY
THALASSEMIA
SIDEROBALSTIC ANEMIA

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7
Q

DECREASE IN THE NUMBER OF RBC PRECURSOR IN THE BONE MARROW

A

INSUFFICIENT ERYTHROPOIESIS

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8
Q

EXAMPLES CONDITIONS OF INSUFFICIENT ERYTHROPOIESIS

A

IRON DEFICIENCY ANEMIA
RENAL DISEASE
ACUTE LEUKEMIA

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9
Q

IMMATURE HEMTAPOIETIC CELL THAT IS COMMITTED TO A CELL LINE BUT CANNOT BE IDENTIFIED MORPHOLOGICALLY

A

PROGENITOR CELLS

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10
Q

IMMATURE HEMATOPOIETIC CELL. THAT IS MORPHOLOGICALLY IDENTIFIABLE AS BLEONGING TO GIVEN CELL LINE

A

PRECURSOR CELLS

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11
Q

EARLIEST MARKER OF ERYTHROID PRECURSOR AND TRANSFERRIN RECEPTOR

A

CD71

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12
Q

EXAMPLES OF HORMONE RELATED TO ERYTHROPOIESIS

A

EPO
GROWTH HORMONE
TESTOSTERONE
PROLACTIN.
ESTROGEN

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13
Q

CHIEF STIMULATOR CYTOKINE FOR RBC

A

EPO

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14
Q

MAJOR HORMONE THATT STMULATES THE PRODUCTION OF RBC

A

EPO

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15
Q

PRIMARY CELL SOURCE OF EPO

A

PERITUBULAR INTERSTITIAL CELL (KIDNEY

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16
Q

PRIMARY TARGET OF EPO

A

BFU-E AND CFU-E

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17
Q

NORMMALLY EPO ISS RELEASED FROM THE KIDNEY INTOO THE BLOOD IN RESPONSE TO ___

A

HYPOXIA

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18
Q

TRANSPORT PROTEIN OF IRON IN THE BLOOD

A

TRANSFERRIN

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19
Q

EPO SIME OF THE CURRENT./ POTENTIAL THERAPEUTIC APPLICATIONS

A

ANEMIA OF CHRONIC RENAL DISEASE
AUTOLOGOUS PREDOMINATION BLOOD COLLECTION
ANEMIA IN HIV INFECTION TO PERMIT USE OF AZT

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20
Q

PRODUCED BY. PITUITARY GLAND
STIMULATES ERYTHROPOIESIS DIRECTLY

A

GROWTH HORMONE

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21
Q

PRODUCED BY TESTES AND STIMULATES ERYTHROPOIESIS INDIRECTLY

___—> KIDNEYS—> EPO—> BM—> RBC

A

TESTOSTERONE

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22
Q

PRODUCED BY PITUITARY GLAND THAT STIMULATES ERYTHROPOIESIS DIRECTLY

A

PROLACTIN

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23
Q

PRODUCED BY OVARIES THAT INHIBITS ERYTHROPOIESIS INDIRECTLY

A

ESTROGEN

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24
Q

EARLIEST COMMITTED PROGENITOR

A

BFU-E

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25
Q

2 COMMITTED ERYTHROID PROGENITOR CELLS

A

BFU-E (BURST- FORMING UNIT- ERYTHROID) AND CFU-E (COLONY FORMING UNIT- ERYTHROID)

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26
Q

HOW MANY WEEK/S FROM BFU-E TO CFU-E

A

1 WEEK

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27
Q

HW MANY WEEK/S FROM CFU-E TO RUBRIBLAST

A

1 WEEK

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28
Q

IT TAKES ABOUT ___ FOR THE BFU-E TO MATURE AND ERYTHROCYTE OF WHICH APPROXIMATELY ___ ARE SPENT RECOGNIZABLE PRECURSOR IN THE B,

A

18-21 DAYS
6 DAYS

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29
Q

ERWER

A
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30
Q

EXAMPLES OF SUPRAVITAL STAIN USED TO DEMONSTRATION OF RETICULOCYTES

A

BCB (BRILLIANT VRESYL BLUE)
NMB (NEW METHYLENE BLUE)

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31
Q

WHEN RETICULOCYTE COUNT ARE FOUND IN A WRIGHT STAIN SMEAR THEY ARE CALLED

A

POLYCHROMATOPHILIC ERYTHROCYTES
DIFFUSELY BASOPHILIC ERYTHROCYTE

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32
Q

MORPHOLOGICAL FEATURES USED TOO IDNTIFY ANS TAGE RBC AND WBC PRECURSOR

A

NC RATIO

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33
Q

PERTAINS TO THE BLUENESS OF A PARTICULAR PART OF THE CELL AND IS DUE TO THE ACIDIC COMPONENT THAT ATTRACT BASIC STAIN

A

BASOPHILIA

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34
Q

PERTAINS TO THE PINKNESS OF A PARTICULAR PART OF THE CELL AND IS DUE. TO THE ACCUMULATION OF MORE BASIC COMPONNETS THAT ATTRACT THE ACID STAIN EOSIN

A

EOSINOPHILIA

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35
Q

EARLIEST RECOGNIZABLE ERYTHROID PRECURSOR USING THE LIGHT MICROSCOPE

A

RUBRIBLAST

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36
Q

COARSER CHROMATIN
ABSENCE OF NUCLEOLI
LAST STAGE WITH NUCLEOLI
ADN 1 STAGE OF HB SYNTHESIS

A

PRORUBRICYTE

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37
Q

LAST STAGE CAPABLE OF MITOSIS
1ST STAGE IN WHICH THE CYTOPLASM IS PINKK

A

RUBRICYTE

38
Q

NUCLEUS IS EXTRUDED AT THIS STAGE AND THE CELL BECEAOMES A RETICULOCYTE
LAST STAGE WITH NUCLEUS

A

METARUBRICYTE

39
Q

LAST STAGE OF HEMOGLOBIN SYNTHESIS

A

RETICULOCYTE

40
Q

HOW MANY DAYS DOES THE RETICULOCYTE SPENDS IN THE BONE MARROW

A

2 TO 3 DAYS

41
Q

HOW MANY DAYS DOES THE RETICULOCYTE SPENDS IN PERIPHERAL BLOOD

A

1 DAY

42
Q

WHAT IS THE SHAPE OF RETICULOCYTE IN THE ELECTRON MICROGRAPHS

A

IRREGULAR

43
Q

NUMBER OF ERYTHROCYTE PRODUCED FROM EACH RUBRIBLAST

A

8-32

44
Q

NORMAL RATIO OF RBC TO WBC

A

600:1

45
Q

NORMAL RATIO OF RBCS TO PLATELET

A

15:1

46
Q

AVERAGE LIFE SPAN OF RBC

A

120 DAYS

47
Q

ENVELOPED EXTRUDED NUCLEUS
ENGUKFED BY BONE MARROW MACROPHAGE

A

PYRENOCYTE

48
Q

RUBRICYTE OR LYMPHOCYTE

NUCLEUS IS CHECKER BOARD
COLOR OF CYTOPLASM IS MUDDY OR GRAY

A

RUBRICYTE

49
Q

RUBRICYTE OR LYMPHOCYTE

NUCLEUS IS CRUSHED VELVET
COLOR OF CYTOPLASM IS SKY BLUE OR RONAN BLUE

A

LYMPHOCYTE

50
Q

RUBRIBLAST GIVES RISE TO ____ PRORUBRICYTES

A

2

51
Q

THE PRORUBRICYTE GIVES RISE TO _____

A

4 RUBRICYTE

52
Q

WHAT ARE THE RBC MEMBRANE CONSTITUENTS

A

8% CARBOHYDRATES
40% LIPIDS
52% PROTEINS

53
Q

ALSO PROVIDE THE VERTICAL SUPPORT CONNECTING THE LIPID BILAYER TO TEH UNDERLYING CYTOSKELETON TO MAINTAIN MEMBRANE INTEGRITY

A

TRANSMEMBRANE PROTEIN

54
Q

EXAMPLES OF TRANSMEMBRANE PROTIEN

A

AQUAPORIN 1
BADN 3
CA 2+ ATPase
duffy
GLUT 1
GLYCOPHORIN A
GLYCOPHORIN B
GLYCOPHORIN C
ICAM 4
KELL
KIDD
RH
RHAG

55
Q

FX OF THS TRANSMEMBRANE PROTEIN IS WATER TRANSPORTER

A

AQUAPORIN 1

56
Q

FX OF THS TRANSMEMBRANE PROTEIN IS ANION TRANSPORTER AND SUPPORT ABH ANTIGENS

A

BAND 3

57
Q

FX OF THS TRANSMEMBRANE PROTEIN IS CA2+ TRANSPORTER

A

CA2+ ATAPASE

58
Q

FX OF THS TRANSMEMBRANE PROTEIN SUPPORT DUFFY ANTIGENS

A

DUFFY

59
Q

FX OF THS TRANSMEMBRANE PROTEIN GLUCOSE TRANSPORTER, SUPPORT ABH ANTIGEN

A

GLUT-1

60
Q

FX OF THS TRANSMEMBRANE PROTEIN TRANSPORT NEGATIVELY CHARGED SIALIC ACID, SUPPORTS DETERMINANTS

A

GLYCOPHORIN A

61
Q

FX OF THS TRANSMEMBRANE PROTEIN TRANSPORT NEGATIVELY CHARGED SIALIC AICD SUPPORT SS DETERINANTS

A

GLYCOPHORIN B

62
Q

FX OF THS TRANSMEMBRANE PROTEIN TRANSPORT NEGATIVELY CHARGED SIALIC ACID SUPPORTS GERBICH SYSTEM DETERMINANTS

A

GLYCOPHORIN C

63
Q

FX OF THS TRANSMEMBRANE PROTEIN INTEGRIN ADHESION

A

ICAM 4

64
Q

FX OF THS TRANSMEMBRANE PROTEIN ZN 2+ BINDING ENDOPEPTIDASE, KELL ANTIGENS

A

KELL

65
Q

FX OF THS TRANSMEMBRANE PROTEIN UREA TRANSPORTER

A

KIDD

66
Q

D AND CcEe ANTIGENS

A

RH

67
Q

NECESSARY FOR THE EXPRESSION OF D AND CcEe
GAS TRANSPORTER PROBABLY CO2

A

RHAG

68
Q

PROVIDE THE HORIZONTAL OR LATERAL SUPPORT FOR THHE MEMBRANE
THE SHAPE FLEXIBILITY OF THE RBC DEPENDS ON THE SYTOSKLETOON

A

SKELETAL PROTEINS

69
Q

PRIMARY CYTOSKELETAL PROTEINS

A

ALPHA SPECTRIN
BETA SPECTRIN

70
Q

DEFECT N PROTEIN THAT DISTURBS VERTICAL MEMBRANE INTERACTIONS BETWEEN TRANSMEMBRANE PROTEINS AND UNDERLYING CYTOSKELTON LOSS OF MEMBRANE AND DECREASED SURFACE AREA TO VOLUME RATIO

A

HEREDITARY SPHEROCYTOSIS

71
Q

SOLUTION FOR PX WITH SPHEROCYTE

A

SPLENECTOMY

72
Q

MOST SENSITIVE AND SPECIFC TEST TO CONFIRM THE DIAGOSIS OF HS

A

EMA BINDING TEST

73
Q

DEFECT IN PROTEINS THAT DISRUPT THE HORIZONTAL-LINKAGES IN THE PROTEIN CCYTOSKELTON LOSS OF MECHANICAL STABILITY OF MEMBRANE

A

HEREDITARY ELLIPTOCYTOSIS

74
Q

SEVERE DEFECT IN SPECTRIN THAT DISRUPTS HORIZONTAL LINKAGES IN PROTEIN CYTOSKLETON; SEVERE RBC FRAGMENTATION

A

HEREDITARY PYROPOIKILOCYTOSIS

75
Q

DEFECT IN BAND 3 CAUSING INCREASED MEMBRANE RIGIDITY; RESISTANT TO MALARIA AND PREVALENT. IN SOME ARE OF SOUTHEAST ASIA

A

HEREDITARY OVALOCYTOSIS

76
Q

INCREASED MEMBRANE PERMIABILITY TO SODIUM AND POTASSIUM
INCREASED INTRACELLULAR SODIUM CAUSING INFLUC OF WATER
INCREASE IN CELL VLUME AND DECREASED CYTOPLASMIC VISCOSITY
DEFICIENT IN RHAG

A

OVERHYDRATED HEREDITARY STOMATOCYTOSIS

77
Q

INCREASED MEMBRANE PERMEABILITY TO POTASSIUM; DECREASED INTRACELLULAR POTASSIUM RESULTING IN LOSS OF WATER FROM CELL DECREASE IN CELL VOLUME, ADN INCREASED CYTOPLASMIC VISCOSITY

A

HEREDITARY XEROCYTOSIS

78
Q

TYPICAL RBC MORPHOLOGY FOR OVERHYDRATED HEREDITARY STOMATOCYTOSIS

A

STOMATOCYTE
MACRCYTES

79
Q

TYPICAL RBC MORPHOLOGY FOR DEHYDRATED HEREDITARY STOMATOCYTOSIS

A

TARGET CELL
BURR CELLS
STOMATOCYTE

80
Q

RBCS WITH PUDDLED” HEOGLOBIN AT PERIPHERY DESSICIATED CELLS WITH SPICULES

A

DEHYDRATED HEREDITARY STOMATOCYTOSIS

81
Q

MUTATIONS THAT CHANGE MEMBRANE STRUCTURES

A

HEREDITARY SPHEROCYTOSIS
HEREDITARY ELLIPTOCYTOSIS
HEREDITARY OVALOCYTOSIS

82
Q

( DISEASES)MUTATIONS THAT CHANGES MEMBRANE TRANSPORT PROTEIN

A

OVERHYDRATED HEREDITARY STOMATOCYTOSIS
DEHYDRATED HEREDITARY STOMATOCYTOSIS

83
Q

RARELY DONE BECAUSE OF INACCURACY AND QUESTIONABLE NECESSITY

A

MANUAL RBC COUNT

84
Q

RBC COUNT, HEMOGLOBIN AND HEMATOCIRT VALUES ARE___ IN PEOPLE LIVING AT A HIGHEER ALTITUDE VER WHAT. THEY WOULD BE AT SEA LVEL

A

ELEVATED

85
Q

THE HB IS ITHE DIFFERENCE OF VALUES IN HIGHER ALTITUDE IS

A

1g/hb/dl at 2km altitude
2g. hb/dl

86
Q

MAJOR GLYCOLYTIC OPATHWAY IN RBC

A

EMBDEN-MEYERHOF PATHWAY

87
Q

HOW MANY. ATP DOES EMBDEN MEYERHOF PATHWAY PRODUCE

A

2

88
Q

MOST COMMON ENZYME DEFICIENCY OF THE EMP AND IS THE MOST COMMON FORM OF HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA

A

PK DEFICIIENCY

89
Q

POSSIBLE PBS FINDING INCLUDES IN PK DEFICIENCY

A

ACANTHOCYTES ADN BURR CELL

90
Q

RECOMMENDED SCREENING TEST FOR PK DEFICIENCY

A

PK FLUORESCENT SPOT TEST

91
Q

SCREENING TEST FOR PK DEFICIENCY

A

AUTPHEMOLYSIS TEST

92
Q

CONFIRMATORY TEST FOR PK DEFICIENCY

A

QUANTITATIVE PK ASSAY

HEMATOLOGY 1 (8 decks)

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