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hematopoiesis Flashcards

1
Q

PROCESS OF BLOOD CELL FORMATION

A

HEMATOPOIESIS OR HEMOPOIESIS

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2
Q

CLASSICAL MARKER OF HEMATOPOIETIC STEM CELL

A

CD 34

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3
Q

HEMATOPOIESIS CONSIDERED TO START AROUND THE ____

A

19TH DAY OF EMBRYONIC DEVELOPMENT AFTER FERTILIZATION

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4
Q

MOST WIDELY ACCEPTED THEORY AMONG EXPERIMENTAL HEMATOLOGIST

A

MONOPHYLETIC THEORY

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5
Q

SUGGESTS THAT EACH OF THE BLOOD CELL LINEAGES IS DERIVED FROM ITS OWN UNIQUE. STEM CELL

A

POLYPHYLETIC THEORY

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6
Q

SUGGEST THAT ALL BLOOD CELLS ARE DERIVED FROM A SINGLE PROGENITOR STEM CELL

A

MONOPHYLETIC THEORY

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7
Q

3 PHASES OF HEMATOPOIESIS

A

MEGALOBLASTIC
HEPATIC
INTRAMEDULLARY

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8
Q

CHIEF SITE OF HEMATOPOIESIS OF MEGALOBLASTIC

A

YOLK SAC

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9
Q

CHIEF SITE OF HEMATOPOIESIS HEPATIC

A

FETAL LIVER
SOME CONTRI (SPLEEN, THYMUS, LYMPH NODES)

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10
Q

CHIEF SITE OF HEMATOPOIESIS OF INTRAMEDULLARY

A

BONE MARROW

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11
Q

1ST BLOOD CELL
IMPORTANT IN EARLY EMBRYOGENESIS Y PRODUCE HEMOGLOBIN NECESSARY FOR DELIVERY OF OXYGE TO THE EMBRYONIC. TISSUES

A

PRIMITIVE ERYTHROBLASTS

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12
Q

PREDOMINANT HEMOGLOBIN DURING HEPATIC PHASE

A

HB F

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13
Q

FIRST FULLY DEVELOPED ORGAN IN THE FETUS

A

THYMUS

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14
Q

PRODUCES B CELLS DURING HEPATIC PHASE

A

KIDNEY AND SPLEEN

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15
Q

HEMATOPOIESIS STARTS IN THE BONE MARROW CAVITY BEFORE THE ______

A

5TH MONTH OF FETAL DEVELOPMENT

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16
Q

BONE MARROW BECOMES THE CHIEF SITE OF HEMATOPOIESIS BY THE _____

A

END OF 24 WEEKS GESTATION

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17
Q

HEMATOPOIETIC TISSUE OF ADULTS ARE LOCATED NOT ONLY N THE BONE MARROW BUT ALSO IN ______

A

LYMPH NODES
SPLEEN
THYMUS
LIVER

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18
Q

CONTAINS THE DEVELPING ERYTHROID
MYELOID
LYMPHOID AND MEGAKARYOCYTIC

A

BONE MARROW

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19
Q

CONSIDERED TO BE A PRIMARY LYMPHOID ORGAN WITH FUNCTIONS EQUIVALENT TO THAT OF BURSAS FABRICIUS

A

BONE MARROW

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20
Q

PROCESS OF REPLACING RED MARROW BY YELLOW MARROW DURING DEVELOPMENT

A

RETROGRESSION

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21
Q

RETROGRESSION HAPPENS ON BETWEEN WHAT AGES?

A

5 AND 7 YEARS OF AGE

22
Q

RETROGRESSION EVENTUALLY RESULTS IN RESTRICTIONS OF THE RED MARROW IN THE ADULT TO THE:

A

RIBS
STERNUM
VERTEBRAE
PELVIS AND PROXIMAL ENDS OF THE LONG BONE

23
Q

HEMATOPOIETICALLY INACTIVE MARROW COMPOSED OF PRIMARILY FAT CELLS

A

YELLOW MARROW

24
Q

HEMATOPOIETICALLY ACTIVE MARROW

A

RED MARROW

25
Q

LARGEST OF THE SECONDARY LYMPHOID ORGA

26
Q

MAJOR ORGANS IN THE BODY IN WHICH ANTIBODIES ARE SYNTHESIZED AND FROM WHICH THEY ARE RELEASED INTO THE CIRCULATION

27
Q

WHAT ARE THE 3 BACTERIA THAT CAN CAUSE BACTERIA SEPSIS IN CHILDREN BECAUSE OF THE SPLENECTOMY?

A

S. PNEUMONIAE
N. MENINGITIDIS
H. INFLUENZAE

28
Q

ANY DISORDER CHARACTERIZED BY A LOCALIZED/GENERALIZED ENLARGEMENT OF LYMPH NODES/. LYMPH VESSELS

A

LYMPHADENOPATHY

29
Q

SOLID TUMORS NEOPLASM OF LYMPHOID TISSUE

30
Q

INCREASED HEMOLYTIIC ACTIVITY OF THE SPLEEN CAUSED BY SPLENOMEGALY

A

HYPERSPLENISM

31
Q

WHAT ARE THE MINOR LYMPHOID ORGANS

A

TONSILS
APPENDIX
PEYER’S PATCH
MALT

32
Q

THIS MINOR LYMPHOID ORGAN FUNCTION IS TO DETECT AND RESPOND TO ANTIGEN IN THE RESPIRATORY AND ALIMENTARY SECRETIONS

33
Q

GENERAL TERM FOR THE UNENCAPSULATED LYMPHOID TISSUE PRESENT IN REGIONS UNDERLYING THE MUCOSAL. AREAS

34
Q

CAN MAINTAIN HEMATOPIETIC STEM CELLS AND PROGENITOR CELLS TO GENERATE VARIOUS BLOOD CELLS

35
Q

PREFERRED SITE FOR BONE MARROW ASPIRATION FOR ADULTS

A

POSTERIOR ILIAC CREST
ANTERIOR ILIAC CREST

36
Q

PREFERRED SITE FOR BONE MARROW ASPIRATION FOR CHILDREN
(<2 YRS OLD)

A

ANTERIOR MEDIAL SURFACE OF THE TIBIA

37
Q

BONE. MARROW COLLECTION SITE

A

POSTERIOR ILIAC CREST
ANTERIOR ILIAC CREST
STERNUM
ANTERIOR MEDIAL SURFACE OF THE TIBIA
SPINOUS PROCESS OF THE VERTEBRAE RIBS OR OTHER RED MARROW CONTAINING BONES

38
Q

BONE MARROW SMEAR SHOULD BE RETAINED FOR

39
Q

INDICATIONS FOR BM EXAMINATION

A

NEOPLASIA DIAGNOSIS
MARROW FAILURE: CYTOPENIAS
METABOLIC DISORDERS
INFECTIONS
MONITORING OF TREATMENTS

40
Q

LARGEST CELL IN A NORMAL MARROW

A

MEGAKARYOCYTES

41
Q

+ NONSPECIFIC (ALPHA NAPTHYL BUTYRATE ESTERASE)

A

MACROPHAGE

42
Q

+ CHLOROACETATE ESTERASE

A

MAST CELLS

43
Q

SYNTHESIZE NEW BONE MATRIX

A

OSTEOBLASTS

44
Q

LARGE, MULTINUCLEATED

A

OSTEOCLASTS

45
Q

IN MARROW DIFFERENTIAL RECOMMENDED

A

AT LEAST 500 CELLS ON EACH OF 2 SLIDES

46
Q

USED FOR ANALYSIS OF INDIVIDUAL CELL MORPHOLOGY
DISTURBS BONE MARROW ARCHITECTURE

A

BON MARROW ASPIRATE

47
Q

USED FOR ANALYSIS OF BONE MARROW ARCHITECTURE

A

BONE MARROW BIOPSY

48
Q

BLOOD CELL PRODUCTION OUTSIDE THE BONE MARROW

A

EXTRAMEDULLARY HEMATOPOIESIS

49
Q

EXTRAMEDULLARY HEMATOPOIESIS OCCURS IN THE FOLLOWING CONDITIONS:

A

BONE MARROW BECOME DYSFUNCTION SUCH AS APLASTIC ANEMIA, INFILTRATED BY MALIGNANT CELLS, AND OVERPROLIFERATION OF CELL LINE LIKE LEUKEMIA

BONE MARROW IS INCAPABLE OF MEETING THE DEMANDS PLACED ON IT (HEMOLYTIC ANEMIA)

50
Q

IN HEALTHY ADULT INDIVIDUAL ME RATIO VARIES ROUGHLY FROM

A

1.5:1 TO 3.3:1

51
Q

IN LEUKEMIA M:E RATIO IS

HEMATOLOGY 1 (8 decks)

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