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Summative > Heme onco > Flashcards

Heme onco Flashcards

1
Q

Germ cell mutation
Auer rods on peripheral smear
DX? TX?

A

AML
Chemo/ radiatio
needs BM biopsy

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2
Q

mc malignat disease in children
CNS involvement
DX? TX?

A

ALL
CAR-T cell therapy

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3
Q

malignacy in mature granulocytes
55-60 y/o
Chromosome 9 and 22
DX? TX?

A

CML
oral tyrosine kinase inhibitors

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4
Q

malignacy in mature lyphoid cells
70 y/o
smudge cells on blood smear
DX? TX?

A

CLL
observation vc brutans tris, antibodies, chemo

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5
Q

what is chromosone 9 and 22?

A

9 - BCR- ABI
22 - Philadelphia

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6
Q

B- cell lympoma w/ reed-sternberg cells
painful ingestion of ETOH, painless lymphadenopathy
DX? TX?

A

hodgkins lymphoma
chemo/ radiation

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7
Q

malignancy of plasma cells w/ rouleaux on blood smear and M-spike on urine serum?

A

multiple myeloma

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8
Q

protein misfolding disorder w/ inslouble beta pleated sheets with s/s of macroglossia and raccon eyes?

A

amyloidosis

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9
Q

ringed sideroblasts

A

myeloidsplastic syndrome

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10
Q

overproliferation of erythroid cells w/ increased hgb and decreased epo. DX? TX?

A

polycethemia vera
phlebotomy, hydroxyurea, ruxolitin

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11
Q

overproliferation of mature cells of myeloid lineage. mutation JAK-2, splenomegally?

A

myeloproliferative disorder/ neoplasm

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12
Q

overproduction of platelets > 450,000?

A

thrombocytothemia

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13
Q

very sick presentation. w/ teardrops on blood smear? splenomegally? overproliferation of myeloid stem cells

A

primary myelofibrosis

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14
Q

Hemophila A factor?
B factor?

A

8 and 9

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15
Q

Vitamin B12 subtype after gastric bypass Dx? and how?

A

pernicious anemia
schiling test

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16
Q

occurs after eatig fava beans. heinz bodies and bite cells on smear?

A

G6PD

17
Q

do not take what w/ g6pd

A

nitrofurantin

18
Q

Thalassemia has what cells?

A

target

19
Q

sideroblastic anemia tx?

A

B6

20
Q

sickle cell disease tx?

A

hydroxyurea

21
Q

howell-jolly bodies seen in what?

A

hereditary spherocytosis

22
Q

normal homocystine and methamalonic is?

A

folate deficiency

23
Q

increased homocystine and methyl is?

A

Vit B12 deficiency

Summative (14 decks)

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