Heme Onc Review Cards Flashcards
Receptor for EBV
Cd21, C3d receptor
CD 14
Marker for moncytes and macrophages, LPS receptor
Atypical Cells in mono
CD8 positive. Increased Cd8/CD4 ratio. IgM is secreted and is used for heterophile Ab test
Changes to Hgb in CO poisoning
- Carboxyhemoglobin. Binds 250x stronger than O2
- Causes a shift to the left leading to decreased offloading in tissues
Electrolyte abnormalities in RBC infusions
- Hyperkalemia from RBC lysis in storage and transfusion
- Hypocalcemia from citrate which is a chelator (usually removes Ca to prevent coagulation in collection and storage)
Methemoglobinemia
- When Fe 2+ goes to Fe 3+.
- Commonly caused by drugs or oxidative stress or nitrates (cyanide)
- Tx is methylene blue which will directly reduces oxidized hemoglobin
Henoch SP
- IgA complexes often following viral infection in kid
- Abdominal colick, purpura, nephrotic syndrome
CMV receptor
-Binds to GAGs on cell surface
Parvo Virus fetal tropic and receptor
-Fetal liver and heart, binds P Ag
Demrazoxone
-Given with DDDDDoxyrubicin, Fe chelator prevents cardiotoxicity
Amifostine
-Given with cisplatin to prevent nephrotoxicity and ototoxicity
Hematopoesis in utero
- Majority in early (0-7 mos) in yolk sac
- Later (8-9 mos) in liver
- Adult is BM
- Some early post partum in LN and spleen
Cyanide Poisoning Antidote and Mechanism
- Normally Cyanide will bind to ETC and cuase death of cells.
- If hemobglobin is oxidized to methemoglobin then cyanide will bind hemoglobin instead.
- Amyl Nitrate oxidizes hemoglobin to methemoglobin which then sequesters cyanide in the RBCs allowing for ETC to function normally
- Cyanide is then eliminated slowly
HIV Nef Gene
Decreases MHCI expression on infected cells reducing vulnerability to CD8 cells
HIV tat gene
-Important in viral replication
