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Boards Drugs > Endocrine Drugs > Flashcards

Endocrine Drugs Flashcards

1
Q

Insulin

A
  • Causes increase in glucose uptake and stimulation of Na/K ATPase to decrease plasma K
  • Used in Diabetes and to correct life threatening hyperkalemia
  • Toxicity is hypoglycemia
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2
Q

Lispro

A

-IV rapid acting

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3
Q

Aspart

A

-SubQ rapid acting

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4
Q

Glulisine

A

-SubQ rapid acting

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5
Q

Regular

A

-IV Short Acting

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6
Q

NPH

A

-SubQ intermediate acting

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7
Q

Glargine

A

-SubQ long acting

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8
Q

Detmir

A

-SubQ long acting

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9
Q

Lente

A

-SubQ Long acting

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10
Q

Metformin

A
  • Biguanide. unknown mechanism but decreases gluconeogenesis and stimulates glycogenolysis
  • Euglycemic and can be used in pts without islet cells
  • Tox: Lactic Acidosis, contraindicated in renal failure
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11
Q

Sulfonylureas

A
  • Close K channel and cause increased Insulin release

- Tox: May cause hypoglycemia and weight gain, also sulfa allergies.

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12
Q

Tolbutamide

A

Sulfonylurea with disulfiram

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13
Q

Chlorprpamide

A

Sulfonylurea with disulfiram

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14
Q

Glyburide, glypizide, glimeperide

A

Sulfonylurea witout disulfiram but other tox remain

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15
Q

Glitazones

A
  • Work through PPAR gamma to increase sensitivity to insulin
  • Rosi and Pio
  • Tox: weight gain and hepatotoxicity, P450, sulfa allergy
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16
Q

Acarabose, Miglitol

A
  • inhibit alpha glucosidases decreasing post prandial hyperglycemia
  • Tox: Flatulance and GI distress
17
Q

Pramlintidine

A
  • Amylin analog, decreases glucagon secretion

- Tox: Hypoglyceima

18
Q

Exenatide, Liraglutide

A
  • GLP-1 analogs that decrease glucagon and increase insulin. Also increase satiety and cause weight loss
  • Tox: N/V and hepatotox
19
Q

Linagliptin, Saxagliptin, Sitagliptin

A
  • Inhibit DPP-4 breakdown of GLP-1 incretin leading to increase insulin release and decrease glucagon
  • Weight loss
  • Minimal S/E
20
Q

PTU

A
  • Inhibits thyroid peroxidase to treat hyperthyroidism and thyroid storm. Also inhibits 5’ deiodinase
  • Safe to use in pregnancy, increased protein binding
  • Tox: Hepatotoxic and aplastic anemia
21
Q

Methimazole

A
  • Inhibits thyroid peroxidase to treat hyperthyroid and thyroid storm
  • Teratogen and contraindicated in pregnancy
  • No hepatptpx
22
Q

Desmopressin

A
  • Central DI (mainly V2 receptors)
  • Also treats vWF disease by releasing WP bodies
  • Also used for enuresis
23
Q

Demeclocycline

A

-Inhibits ADH used for SIADH

Boards Drugs (18 decks)

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