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Integrative Week Two > Heme/Immune > Flashcards

Heme/Immune Flashcards

1
Q

B12 def

A

neuro findings, high MCV

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2
Q

causes of B12 def

A

pernicious anemia (anti-IF Ab)
terminal ileitis
vegan

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3
Q

B12 def with normal B12

A

high homocysteine and methylmalonic acid

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4
Q

G6PD def

A

post sulfa drug hemolytic anemia

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5
Q

Hereditary Spherocytosis

A

mild anemia
high MCHC
splenomegaly
family history

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6
Q

Hyperhemolytic crisis

A

vaso-occlusion
splenic-sequestion
sickle cell patient profoundly anemic

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7
Q

Sickle Cell Complications

A

acute chest syndrome
salmonella osteomyelitis
avascular necoris of femoral head

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8
Q

Vaccines to give someone without spleen

A

pneumococcal
mening
Hib
(encapsulated)

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9
Q

TTP

A

fever, mental status changes
SCHISTOCYTES
renal dysfunction, low platelets

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10
Q

Cause of TTP

A

ADAM TS-13/vWF cleaving protease

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11
Q

CLL

A

older, massive LAD
spleen
WBC 30K with lymphs

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12
Q

CML

A

high WBC in all lines
mild illness
9:22/brc-abl translocation

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13
Q

CML treatment

A

imatinib

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14
Q

Acute promyelocytic leukemia

A

15:17 translocation

treat with all-trans-retinoic acid

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15
Q

Multiple Myeloma

A

anemia, renal failure, older

high Ca, high prot,albumin, narrow anion gap

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16
Q

Multiple Myeloma mechanism

A

osteoclast activating factors (Il-6)

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17
Q

ITP

A

post URI, normal WBC, HCT, platelets 5K

megakaroycytes on bone marrow biopsy

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18
Q

HUS

A

toxogenic E coli
child, bloody diarrhea than AKI
thrombocytopenia, anemia

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19
Q

Cis-platin/carboplatin

A

nephrotoxicity

acoustic nerve damage

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20
Q

Bleomycin/busulfan

A

pulmonary fibrosis

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21
Q

Vincristine

A

pierpheral neuropathy

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22
Q

Doxorubicin

A

cardiotoxicity

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23
Q

cyclophosphamide

A

hemorrhagic cystitis

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24
Q

Trastuzumab

A

mab against HER2, tyrosine kinase

CHF

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25
Rituximab
ab against Cd-20 | on most B cell neoplasms (NHL)
26
Omalizumab
anti-IgE | severe asthma
27
Bevacizumab
mab against VEGF | inhibits angiogenesis
28
Infliximab
anti TNF | crohn's, RA
29
Abciximab
anti-glycorotein IIb/IIIa | some acute coronary syndromes
30
Type I Hypersensitivity
preformed antibody igE mediated immediate symptoms
31
examples of Type I hypersensitivity
allergy atopy anaphylaxis
32
Type II Hypersensitvity
cytotoxic rxns of Abs against cells or tissus
33
Examples of Type II hypersensitvity
Hemolytic anemia - Coombs | Goodpastures - antiGBM
34
Type III Hypersensitvity
ag-ab complex deposition in tissue
35
Examples of Type III hypersensitvity
Vasculitis Sle,RA serum sickness, post strep GN, Arthus reaction
36
Arthus reaction
edema necrosis activation of complement
37
Type IV Hypersensitivity
T cell mediated | delayed presentation, 24-48 hrs
38
Examples of Type IV Hypersensitivity
TB skin test contact dermatitis/poison ivy GvH
39
tight skin on face, hands, pulmonary fibrosis, esophageal dysmotility, renal disease
scleroderma - systemic sclerosis | Anti-Scl-70/anti-DNA topoisomerase 1
40
proximal muscle weakness | elevated CK
polymyositis | Anti-Jo-1
41
Asthma, eosinophilia, necrotizing vasculitis
Churgg-Strauss | P-ANCA
42
Autoimmune hepatitis
40 year old women acute, very high transaminases, +ANA anti-smooth muscle antibodies
43
anti-smooth muscle Abs
autoimmune hepatitis
44
anti-liver/kidney/microsomal
autoimmune hepatitis in children
45
Primary Biliary Cirrhosis
middle aged women high alk phosphatase liver dz anti-mitochondrial Abs
46
anti-mitochondrial Abs
PBC
47
celiac disease symptoms
diarrhea, steatorrhea, wt loss
48
celiac labs
anti-tissue transglutaminase (igA) | anti-endomysial
49
Celiac path
blunting of intestinal villi | crypt hyperplasia
50
Agammaglobulinemia
Xlinked/Burton's infant boy, 4-6 months encapsulated organism sepsis absent B cells
51
Common Variable
young adult recurrent sinusitis, pneumoa, bronchiectasis splenomegaly, malignancies GI malabsorption
52
Congential thymic dysplasia (Di George syndrome)
CHD/truncus arteriosus hypoparathyroid facial abnormalities Low T cells
53
Recurrent Neiserria infections
terminal complment, C5-C9 deficiency
54
Chronic Granulomatous Disease
boy, chronic catalase + infections (Staph, Ecoli, Serratia, Aspergillus) nitroblue terazolium
55
Chediak-Hegashi
AR chronic granulomatous disease
56
Oculocutaneous Albinism
chornic granulomatous Disease
57
Wiskott Aldrich
eczema, thrombocytopenia X linked combined B and T cell def
58
SCID
agammaglobulinemia lymphopenia infant
59
Cause of SCID
adenosine deaminase def | defected IL-2 receptors
60
Leukocyte adhesion def
``` infant recurrent bacterial infections persistent neutrophilia absent pus delayed separation of umbilical cord ```
61
transfusion | urticarial, pruritis, wheezing, fever
allergic rxn type 1 hypersen against plasma proteins in transfused blood
62
dyspnea, bronchospasm, hypotension, resp arrest, post tranfusion
anaphylactic rxn | IgA def patients get this from Abs to IgA after transfusion
63
fever, chills within 12 hours of transfusion | no hemolysis
febrile, nonhemolytic transfusion rxn Type II, host antibodies veruse donor Ags and WBCs (most blood banks remove WBCs now)
64
transfuion fever, hypotension, flank pain, brown urine immediate
acute hemolytic transfuion rxn | ABO mismatch
65
jaundice | slow hemolysis 1-2 weeks after transfusion
delayed hemolytic transfusion rxn anti-Kell, Duffy extravascular, previous exposure
66
shortness of air during transfusion | crackles
volume overload
67
fever, dyspnea, noncardiogenic pulmonary edema on CXR esp after FFP
transfusion associated acute lung injury

Integrative Week Two (17 decks)

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