Hematopoiesis

Question 1

What 3 additional labs are used to distinguish between MICROcytic anemias?

Answer 1

1. Ferritin levels
2. TIBC ( transferrin iron binding capacity)
3. serum Fe levels

Question 2

Pt presents with MCV of 70 fL/cell and is diagnosed with sideroblastic anemia. Which of the following is true regarding the cause of this value?

1. decreased Hb production
2. decreased DNA repair mechanisms
3. decreased blood volume
4. decreased EPO

Answer 2

1. Microcytic anemia is due to decreased Hb production.
   - causes include deficiency in Fe or not enough HEME.
2. is a potential cause for MACROCYTIC anemia

3/4 are related to NORMOCYTIC anemia

Question 3

A mother comes in c/o that her infant has pale yellowish skin and cold hands and feet. When asked about the childs diet the mom states it is primarily cow’s milk that is being given to the child. What do you expect the childs MCV value to be ?

Answer 3

< 80 , MICROCYTIC ANEMIA, due to iron deficiency in his cow milk diet.

Iron deficiency is classified as microcytic and is the most common nutritional disorder. The cows milk diet is lacking in IRON

slide 28 Hematopoiesis

Question 4

What would you use therapeutically to treat neutropenia?

Answer 4

G-CSF , stimulates maturation of NEUTROPHILS

Question 5

What would you use to stimulate platelet production?

Answer 5

TPO

Question 6

What Hematopoietic factor sensitizes the precursors to other growth factors?

Answer 6

SCF