Drugs/ Treatments

Question 1

Rampamycin

Answer 1

INhibits IGF-1. which is a signal for glucose availbaility. Rampamycin would then be promoting a state of caloric restriction therefore increasing longevity

Question 2

Zileuton

Answer 2

inhibtis 5-lipoxyogenase, decreases synthesis of leukotrienes (which recruit neutrophils and increase vascular permeability)

this drug can help ASTHMA

Question 3

Montelukast/ Xafirluekast

Answer 3

inhibtis leukotriene RECEPTORS : decreases action of leukotrienes (which recruit neutrophils and increase vascular permeability)

Question 4

Aspirin

Answer 4

1. REDUCE FEVER: inhibit cyclooxygenase for PGS synthesis

2. REDUCE CLOTTING: inhibits thromboxane A2 that helps with clot aggregation

Question 5

Patient who is on prolonged corticosteroids has suppressed immune function. Explain what corticosteroids do?

Answer 5

They decrease conversion of phospholipases to arachidonic acid. There fore decreasing synthesis of leukotriens and PGS.