Hematology Flashcards
What are erythroblasts?
Baby red blood cells
Do mature red blood cells have DNA?
No they have no DNA or RNA which means they can’t synthesize proteins for cell functions
What is the lifespan of a red blood cell?
100 to 120 days
How many days does it take for a stem cell to differentiate into a mature red blood cell?
Seven days
What are the four components of blood cells?
There are leukocytes, lymphocytes, erythrocytes, and platelets.
Where is blood composed of in the fetus?
The liver
where is blood composed of in children and adults? 4 places
Ribs, sternum, vertebrae, Ilium
What is the shape of a red blood cell?
Biconcave
What is hemoglobin?
Iron containing protein
What organ can detect when there is an increase need for oxygen?
The kidneys Can detect the need
What do kidneys secrete when there’s a need for additional red blood cells?
Erythropoietin
Iron, folate, vitamin B12 and intrinsic factors help support what?
Erythropoiesis
Where is iron absorbed from?
The G.I. tract
Iron stored in the liver is called what?
Ferritin
Iron is transported as what to the liver?
Transferrin
From the liver ferritin is transported as what to the bone for incorporation in hemoglobin?
Transferrin
Two alpha chains in the fetus composes what type of hemoglobin
Hemoglobin F
How many weeks out after birth, does the alpha chains and the beta chains pair to result adult hemoglobin A.
18 weeks-24 weeks after birth
What is the four unit structure hemoglobin called?
Tetramer
What is a normal RBC count?
4.2–6.2
What is the hematocrit range?
37-52%
Females: 37-47%
Males: 42-52%
What is the normal hemoglobin range?
12 to 18 (think difference of 4 from the highest and lowest)
Females: 12–16
Males: 14–18
1g of hemoglobin is about how much percentage of hematocrit?
3% of hematocrit
What type of genetic disorder is pernicious anemia?
Autosomal recessive genetic disorder
What is pernicious anemia?
Deficiency of intrinsic factor in resulting in the inability to absorb vitamin b12
What is vitamin b12 deficiency anemia?
Due to dietary deficiency or impaired intestinal absorption, rather than lack of intrinsic factor
What disease or conditions are associated with vitamin B 12 deficiency?
Crohn’s disease Celiac disease Vegetarianism Excessive alcohol consumption Acid reducing medication
What does the Schilling test confirm?
Confirms low vitamin b12 level is due to intrinsic factor deficiency
