Hematology

Question 1

VitB12 Deficiency

Answer 1

Megaloblastic
Periph Neuropathy
MMA

Question 2

Folate Deficiency

Answer 2

Megaloblastic

NO NEURO Sx

Question 3

Fe2+ Deficiency

Answer 3

May be d/t blood loss
Microcytic
Low Ferritin

Question 4

Anemia of Chronic Disease

Answer 4

Micro/normocytic

Ferritin WNL

Question 5

Hemolysis

Answer 5

Inc LDH, retic, indirect bili

Dec haptoglobin

Question 6

Aplastic Anemia

Answer 6

Pancytopenia, low retic

Dx: Bone biopsy

Question 7

G6PD Deficiency

Answer 7

X-linked enzyme deficiency
+Bite cells & Heinz bodies
Infection, Fava beans

Question 8

VonWillebrand

Answer 8

Most common bleeding disorder
Elevated aPTT
vWF activity
RIPA
Tx: Desmopressin

Question 9

Hemophilia

Answer 9

X-linked rec
Hemarthrosis
Plt WNL
Prolonged aPTT

Question 10

Factor V Leiden

Answer 10

Thrombophilia
No screening
Risk inc for: DVT, PE

Question 11

Antiphospholipid Syndrome

Answer 11

+Anticardiolipin AB
Prolonged aPTT
Russel Viper Venom test
Recurrent preg loss, risk inc for DVT

Question 12

HIT

Answer 12

4+ days
Thrombosis
Dx: ELISA
Risk of venous limb gangrene

Question 13

CML

Answer 13

Neutros
Basophilia
Leukocytosis
d/t 9:22 transloc (Philadelphia chromosome)
Tx: RTKi

Question 14

CLL

Answer 14

Non-functioning B cells
Lymphadenopathy & lymphocytosis
Dx: flow cytometry
Tx: Rituximab

Question 15

Hodgkin Lymphoma

Answer 15

Painless cervical lymphadenopathy
B Sx
+Reed Sternberg cells
Mediastinal mass –> excisional node biopsy to Dx

Question 16

Multiple Myeloma

Answer 16

Plasma cells, IgG, IgA
+Bence-Jones proteins
Rouleaux formation
>10% clonal plasma cells

Question 17

SCA

Answer 17

Vaso-occlusion
Hemolytic anemia
Sx when cold/hypoxic/EtOH/infec
\+Howell-Jolly bodies
Tx: PCN if <5yo; Hydroxyurea