Hematology Flashcards
The initial Hgb value during active bleeding may be
normal; it takes approx 24 hours after hemorrhage for CBC to show true H/H.
s/s of Vitamin B12 deficiency
peripheral neuropathy, ataxia, impaired memory, dementia
a cancer of the b cells
Hodgkin’s lymphoma
risk factors for Hodgkin’s lymphoma
age 20-40 or older than 60, white, male
s/s of Hodgkin’s lymphoma
night sweat, fever, pain with ingestion of alcohol, painless enlarged neck lymph nodes, anorexia
A cancer of B cells and killer cells
Non-Hodgkin lymphoma
risk factor for Non-Hodgkin lymphoma
greater than 60 years old
which lymphoma has worse prognosis
non-hodgkin
a cancer of the plasma cells
multiple myeloma
s/s of multiple myeloma
fatigue, weakness, and bone pain in back or chest
diagnostic findings in multiple myeloma
proteinuria with Bence-Jones protein, hypercalcemia, normocytic anemia
thrombocytopenia is
platelet less than 150,000
normal platelet count
150,000 - 450,000
bruising in children
normal if in distal upper and lower extremities. Abnormal if accompanied by petechiae/purpura, large hematomas
Normal H&H in males
Hgb: 14-18
Hct: 42-52%
Normal H&H in females
Hgb: 12-16
Hct: 37-47%
Hgb in those who live in high-altitude areas are
elevated (secondary polycythemia)
a measure of the avg color of the RBC in a sample of blood
MCHC
A measure of available transferrin that is left unbound to iron
TIBC
TIBC is elevated in ____
iron deficiency anemia b/c there is not enough iron for transport
labs in thalassemia
low H&H, low MCV, low MCHC, low MCH, normal TIBC, high RDW, normal ferritin
Most sensitive test for iron deficiency anemia
serum ferritin
measure of the variability of the size of RBC
RDW
reticulocytes are immature RBCs that still have ____; they mature into RBC in
nuclei; 24 hours
reticulocytosis occurs after
supplementation of iron, vit B12, folate, acute bleeding, hemolysis, leukemia
poikilocytosis is seen with
severe iron deficiency anemia
Types of microcytic anemia
iron deficiency, thalassemia, sideroblastic
Types of macrocytic anemia
vitamin B12, folate deficiency, pernicious
Types of normocytic anemia
anemia of chronic disease, sickle cell, aplastic, hemolytic
gold standard test to diagnose for sickle cell and thalassemia
hemoglobin electrophoresis
causes of secondary polycythemia
chronic smokers, COPD, residents of high-altitude
s/s of iron deficiency anemia
fatigue, pallor, glossitis (shiny red tongue), angular chelitis (irritated fissures at corners of mouth), pica.