Hematology

Question 1

What is a deficiency in erythrocytoes that predisposes individuals to hemolysis in the presence of infecion, meds, stress

Answer 1

Glucose-6 phosphate dehydrogenase

Question 2

What causes increased indirect bilirubin and low haptoglobin

Answer 2

hemolysis (both intravascular and extravascular)

Question 3

Genetic mutation that causes impaired conjugation of bilirubin. Serum aminotransferases and alk phos are normal. No treatment

Answer 3

Gilbert’s syndrome

Question 4

type of bilirubinemia that occur when the liver cells are able to conjugate bilirubin but are unable to remove it from the biliary system

Answer 4

conjugated hyperbilirubinemia

Question 5

an inherited (autosomal recessive) genetic disorder that causes direct hyperbilirubinemia by a bile transport abnormality. No treatment indicated.

Answer 5

dubin johnson

Question 6

associated with modest elevation of direct bilirubin but disproportionately greater elevation in serum alkaline phosphatase

Answer 6

metastatic tumor in the liver

Question 7

associated with modest elevation of direct bilirubin but disproportionately greater elevation in serum alkaline phosphatase

Answer 7

metastatic tumor in the liver

Question 8

20 year old African American male is started on primaquine for malarial prophylaxis and one week later notices juandice and dark brown urine. He has a hemoglobin of 10 total bili of 3.8 and unconjugated bili of 3.1. what is the most likely diagnosis

Answer 8

Glucose-6 phosphate dehydrogenase (G6 PD) deficiency

Question 9

free hemoglobin that is releae durign intravascular and extravascular hemolysis binds to this molecule. During hemolysis there is less of this

Answer 9

haptoglobin

Question 10

why is there increased serum lactic dehydrogenase during hemolysis?

Answer 10

It is released from erythrocytes