GI part 1 Flashcards
What are the 2 main types of esophagitis?
Non-infectious (medications, eosinophilic)
Infectious (HSV, CMV, Candidiasis)
What medications can cause non-infectious esophagitis in Elderly patients?
*Bisphosphonates (alendronate) Tetracyclines NSAID KCl teenagers - doxycycline
Patients that have asthma or allergies have a higher possibility of having what type of esophagitis?
eosinophilic (check with biopsy)
Treatment for eosinophilic esophagitis?
diet modification (based on allergy screening), PPI, glucocorticoids, budesonide (topical steroids to reduce inflammation)
What are the 2 common viral etiologies of infectious esophagitis?
HSV
CMV
Fungal esophagitis?
Candidiasis
seen in immunocompromised patients - HIV, Cancer, Bone marrow transplant
What type of esophagitis has small shallow volcano like vesicles and treatment?
HSV
Acyclovir
What type of esophagitis is common in HIV patients and the ulcer is deeper and wide and treatment?
CMV
ganciclovir IV
What type of esophagitis presents with white mucosal plaque-like lesions with odynophagia (painful swallowing) and whats the treatment?
candidiasis
(stain on KOH will show yeast)
fluconazole or ketoconazole
What are the 8 types of dysphagia?
Achalasia Esophageal Spasm Scleroderma Neurologic Disease Strictures Schatzki Ring Cancer Esophageal Web
What dysphagia is sensitive to solids and liquids…..degeneration of Auerbach’s plexus…. bird/parrot beak on barium swallow?
Treatment?
achalasia
Tx: muscle relaxants, nifedipine (CCB), botox, myotomy
confirm by manometry
What dysphagia is sensitive to solids and liquids… cork screw on barium swallow?
Treatment?
Esophageal Spasm
Tx: muscle relaxants, nifedipine, botox, myotomy
What dysphagia is sensitive to solids and liquids… may manifest in GI tract due to decreased esophageal sphincter tone…
scleroderma
What dysphagia is sensitive to solids and liquids… suspect if pt had CVA or parkinson’s or alzheimers?
Neurologic disease
What dysphagia is sensitive to solids…and from the healing process of ulcerative esophagitis (scarring)?
Diagnosis and treatment?
Strictures
Get endoscopy with dilatation (treatment)
What dysphagia is sensitive to solids and is caused by a muscular band near LES?
Schatzki ring
What cancerous dysphagia is from a smoker and etoh?
squamous cell carcinoma
world wide most common
What cancerous dysphagia is from Barrett’s?
columnar or adenocarcinoma
US most common
What dysphagia is sensitive to solids and iron deficiency anemia and esophageal webs?
plummer-vinson
What are the most common symptoms for esophageal neoplasm… diagnosis and treatment?
progressive dysphagia to solids
wt loss
Endoscopy w/cytology
CT for staging
chemo + surgical resection
linear mucosal tear in the esophagus after forceful vomiting or retching… causing hematemesis?
Mallory Weiss Tear
How do you diagnose and treat a Mallory Weiss Tear?
endoscopy
Tx: self limiting
-can use endoscopy with injection and thermal coagulation if bleeding does not resolve on own.
What is caused by severe retching and vomiting followed by excruciating retrosternal chest and upper abdominal pain… odynophagia (pain), fever, shock?
Boerhaave’s = surgical emergency!!
what esophageal disease is caused by dilations of veins due to portal hypertension caused by cirrhosis?
Esophageal Varices
Patient presents with painless upper GI bleed, and signs of liver disease (jaundice, palmar erythema)
Esophageal varices
Treatment of esophageal varices?
Prevention = BB (nadolol or propranolol)
Endoscopic hematostasis with injection sclerotherapy and variceal band ligation
Correct coagulopathy and transfuse PRN
Symptoms = heartburn, hoarseness, regurgitation of food, atypical chest pain, cough, Barrett’s esophagitis?
GERD
What is the diagnosis for GERD?
pH monitoring = gold standard
Decrease LES pressure
Biopsy for H. Pylori
Treatment for GERD
Lifestyle modifications - smoking, avoid large meals. laying down
Antacids
H2 blockers (cimetidine, famotidine) PPI (omeprazole) Nissen Fundoplication
What medications can worsen GERD?
antibiotics (tetracycline) bisphosphonates iron NSAID anticholinergic CCB narcotics Benzo
Dyspepsia and abdominal pain…H Pylori/NSAID…may present with GI bleed?
PUD (peptic ulcer disease)
What is diagnosis for PUD?
Upper GI endoscopy
Biopsy for H. pylori (breath test)
What disease is pain with food?
peptic ulcer
What disease is pain after food?
duodenal ulcer
Treatment for H. Pylori PUD?
PPI, amoxicillin, clarithromycin x 7-14 days
or
PPI, clarithromycin + metronidazole
or
PPI, bismuth subsalicylate + tetracycline, metronidazole
What are causes of gastritis?
NSAID
Alcohol
H. pylori
What is delayed gastric emptying?
Gastroparesis
What are the causes of gastroparesis?
Myopathic diseases of smooth muscles and neurological dysfunction
-diabetes
Treatment for gastroparesis? (Delayed gastric emptying)
Pro kinetic meds = cisapride and metoclopramide
What are the 4 gastric neoplasms?
Zollinger-Ellison syndrome
Gastric adenocarcinoma
Carcinoid tumor
Gastric lymphoma
What happens in Zollinger-Ellison syndrome?
A gastrin secreting tumor (gastrinoma) causes hypergastrinemia = which results in refractory PUD
What test do you order for suspecting Zollinger-Ellison syndrome?
Fasting gastrin >150
Secretin test
Endoscopy/CT/MRI localize tumor
Treatment for gastrinoma?
PPI
Surgical resection
What gastric cancer is associated with h pylori and cigarette smoking?
Gastric adenocarcinoma
Patient is >40, dyspepsia, wt loss, iron deficiency anemia, occult GI bleeding
Order endoscopy with cytology (anyone over 40 with dyspepsia), then CT to see extent of disease
Gastric adenocarcinoma
Treatment for gastric adenocarcinoma?
Curative or palliative resection
Chemo or radiation
What is Virchow node vs sister Mary Joseph nodule?
Virchow = left supra ventricular lymphadenopathy
Sister Mary Joseph = umbilical nodule
The risk of gastric lymphoma is greater by 6 fold if ______ is present?
H pylori
S/S of gastroparesis?
post prandial hypoglycemia despite eating, post prandial n/v
Which gastric cancer is the most common site of extra-nodal site of non-Hodgkin’s lymphoma?
gastric lymphoma, <2% of gastric cancers
Tx: same as adenocarcinoma = surgery
What are the primary sites of gastric cancer metastasis?
liver
peritoneum
lung
what are the 4 diseases of the biliary tract (gallbladder)?
Cholelithiasis
acute cholecystitis
cholangitis
cancer
What are some risk factors for cholelithiasis?
- increasing age, pregnancy, estrogen, obesity
- cirrhosis
- clofibrate
- ceftriaxone
- sickle cell disease, Crohn’s
- hereditary spherocytosis
Pain is episodic, after fatty meals in RUQ, may have some n/v, normal exam between episodes?
cholelithiasis
What are the 5 F’s for cholelithiasis?
female, fat, forty, fertile, flatulent
What is Murphy’s sign?
acute cholecystitis
-severe pain when breathing in and palpating RUQ
Patient has Murphy’s sign, n/v, fever, chills, anorexia, elevated WBC and LFT?
acute cholecystitis
First step in diagnosing acute cholecystitis?
Ultrasound = stones/sludge; wall thickening +/- pericholecystic fluid
Biliary Scan
Treatment for acute cholecystitis?
ERCP = biliary obstruction/choledocholithiasis
Surgery = ABX therapy (laparoscopy vs open cholecystectomy)
What is a HIDA scan?
nuclear scan of gall bladder
What is Fitz-Hugh-Curtis?
gonococcal infection causing perihepatitis that looks like cholecystitis
What is Charcot Triad?
Cholangitis
-fever, jaundice, RUQ pain
What is Reynold’s pentad?
Cholangitis
-fever, jaundice RUQ pain
+ confusion and hypotension (acute obstructive)