GYN Flashcards

1
Q

What phase is day 1-14 of menstruation?

A

follicular phase

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2
Q

describe the hormones related to follicular phase (day 1-14)

A
  • FSH, LH receptors upregulate
  • low progesterone levels
  • estrogen is the dominant hormone
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3
Q

What happens on day 14 of menstruation?

A

ovulation occurs and LH surge

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4
Q

what phase is day 15-28?

A

luteal phase

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5
Q

describe what happens during the luteal phase (day 15-28)

A
  • corpus luteum develops and produces progesterone and estrogen
  • progesterone is the dominant hormone
  • endometrial vascularity and secretory action increase
  • increases basal body temp
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6
Q

When is the proliferation phase?

A

days 1-14

endometrium

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7
Q

When is the secretory phase?

A

days 15-28

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8
Q

When is the secretory phase?

A

days 15-28

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9
Q

symptoms (wt gain, edema, mood changes, breast tenderness, anxiety, depression) occur in the luteal phase (day 15-28)

symptoms end 1-2 days after onset of menses

A

premenstrual syndrome (PMS)

must have somatic and affective symptoms

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10
Q

if premenstrual symptoms are severe enough to cause dysfunction of daily living?

A

premenstrual dysphoric disorder (PMDD)

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11
Q

Treatment for premenstrual syndrome?

A
  • NSAID
  • Diuretics
  • SSRI (fluoxetine, sertraline, paroxetine)
  • OCP
  • diet and behavior changes = decrease caffeine, low carbs, vit b6, water, calcium, exercise
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12
Q

primary dysmenorrhea?

A

painful menstruation = excess prostaglandin and leukotriene levels

  • onset within 2 years of menarche
  • no pathologic abnormality
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13
Q

Secondary dysmenorrhea?

A
  • painful menstruation = later in life

- identifiable cause

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14
Q

Examples of causes for secondary dysmenorrhea?

A
  • cervical stenosis
  • endometriosis
  • adenomyosis
  • pelvic infection
  • adhesion
  • pelvic congestion
  • conditioned behavior
  • stress
  • GI
  • IUD
  • fibroids
  • PID
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15
Q

Treatment for primary dysmenorrhea?

A
  • NSAID before onset of menses and continue for 2-3 days (first line)
  • OCP (2nd line), vit b, magnesium, heat, exercise
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16
Q

treatment for secondary dysmenorrhea?

A

treat underlying condition

  • remove IUD
  • symptomatic
17
Q

treatment for secondary dysmenorrhea?

A

treat underlying condition

  • remove IUD
  • symptomatic
18
Q

high fever, hypotension, v/d, rash, confusion, HA, seizures, retained tampon… suspect? cause? treatment?

A

toxic shock syndrome

cause: toxins from staphylococcus aureus or group a streptococcus

Tx: Clindamycin IV

  • surgical debridement
  • consider MRSA
19
Q

high fever, hypotension, v/d, rash, confusion, HA, seizures, retained tampon… suspect? cause? treatment?

A

toxic shock syndrome

cause: toxins from staphylococcus aureus or group a streptococcus

Tx: Clindamycin IV

  • surgical debridement
  • consider MRSA
20
Q

What is the absence of menstruation by age 16?

A

primary amenorrhea

21
Q

Causes of primary amenorrhea?

A
  • gonadal agenesis or dysgenesis (turner syndrome)
  • GNRH deficiency
  • constitutional pubertal delay
  • hyperprolactinemia
  • ovarian resistance syndrome
  • stress
  • CNS mass
22
Q

absence of menstruation at age 16, has breast development, no pubic or axillary hair… what type of primary amenorrhea?

A

androgen insenstivity

23
Q

absence of menstruation by age 16, has normal secondary sexual characteristics.. what could be some of the causes for this type of primary amenorrhea?

A
  • imperforate hymen
  • vaginal septum
  • mullerian agenesis
24
Q

Workup for primary amenorrhea?

A
  • full H&P
  • quantitative beta-hCG
  • FSH, prolactin, TSH, T3,T4, estrogen, progesterone
  • US, MRI/CT r/o CNS, abdominal, pelvic mass
  • genetic testing
25
Q

absence of menstruation by age 16, and incomplete development of sexual characteristics… what could be some of the causes for this type of primary amenorrhea?

A
  • tumor - hypothalamic or pituitary
  • premature ovarian failure
  • hypothyroid
  • hyperprolactinemia
26
Q

absence of menstruation by age 16, and incomplete development of sexual characteristics… what could be some of the causes for this type of primary amenorrhea?

A
  • tumor - hypothalamic or pituitary
  • premature ovarian failure
  • hypothyroid
  • hyperprolactinemia
27
Q

What are the 2 types of secondary amenorrhea?

A
  1. previously menstruated = absence of menses for 3 months if had normal cycles
  2. irregular menses = absence of menses for 6 months
28
Q

most common cause of secondary amenorrhea is ____?

A

pregnancy

29
Q

What are 2 conditions you should rule out for secondary amenorrhea?

A

Asherman’s syndrome

PCOS

30
Q

cessation of menses for at least 12 months?

A

menopause

31
Q

cessation of menses for at least 12 months?

A

menopause

(decrease in ovarian function and estrogen production)

+increase in GNRH and FSH

32
Q

FSH >30, low estradiol

A

menopause

33
Q

What is the condition called if you go into menopause

A

premature ovarian failure

34
Q

Treatment for menopause?

A
  • symptomatic
  • hormonal: estrogen and progesterone replacement
  • calcium/vit D = osteoporosis
35
Q

unopposed estrogen if a women still has a uterus?

A

at risk for endometrial cancer

36
Q

What are some contraindications for Hormone replacement therapy?

A
  • elevated Triglycerides
  • undiagnosed vaginal bleeding
  • endometrial cancer
  • hx of breast cancer
  • estrogen sensitive cancer
  • Hx CVC
  • Hx DVT/PE
37
Q

cancer marker for ovarian cancer

A

CA 125