Hematology

Question 1

Coagulation cascade

Answer 1

FA 377

Question 2

Thrombogenesis

Answer 2

FA 379

Question 3

Anemias

Answer 3

FA 382

Question 4

Heme synthesis, porphyrias, and lead poisoning

Answer 4

FA 388

Question 5

Coagulation disorders

Answer 5

FA 389

Question 6

Factor V Leiden

Answer 6

Production of mutant factor V that is resistant to degradation by activated protein C. most common cause of inherited hypercoagulability in whites.

Question 7

Prothrombin gene mutation

Answer 7

Mutation in 3’ untranslated region -> inc production of prothrombin -> inc plasma levels and venous clots

Question 8

Antithrombin deficiency

Answer 8

Inherited deficiency of antithrombin: has no direct effect on the PT, PTT, or thrombin time but diminishes the increase in PTT following heparin administration.
Can also be acquired: renal failure/nephrotic syndrome -> antithrombin -> inc plasma levels and venous clots

Question 9

Protein C or S deficiency

Answer 9

dec ability to inactivate factors V and VIII. inc risk of thrombotic skin necrosis with hemorhage following administration of warfarin. Skin and subcutaneous tissue necrosis after warfarin administration -> think protein C deficiency

Question 10

Hodgkin vs non-hodgkin lymphoma

Answer 10

FA 391

Question 11

Non-Hodgkin lymphoma

Answer 11

FA 392

Question 12

Leukemias

Answer 12

FA 394

Question 13

Chemo-Tax man

Answer 13

FA 407