hematologic cancers

Question 1

t(8:14), starry sky, EBV association, jaw lesion in African children

Answer 1

burkitts lymphoma

Question 2

older adults, most common in adults

Answer 2

diffuse large B cell lymphoma

Question 3

t(14:18), adults, incr bcl-2

Answer 3

follicular lymphoma

Question 4

HTLV1, Japan, W Afr, Caribbean, lytic bone lesions, hypercalcemia, adults present with cutaneous lesions

Answer 4

Adult T cell lymphoma

Question 5

cutaneous patches, indolent, CD4+

Answer 5

myscosis fungiodes/sezary syndrome

Question 6

age under 15, mediastinal mass, association with Downs, TdT+, CD10+

Answer 6

ALL

Question 7

age >60, CD20+, CD5+, B cell neoplasm, smudge cells

Answer 7

CLL

Question 8

adults, fir-like projections, tartrate resistant phosphatase positive

Answer 8

hairy cell leukemia

Question 9

tx of hairy cell leukemia

Answer 9

cladribine (adenosine analog)

Question 10

avg age of onset 65, auer rods, incr circulating myeloblasts, Down syndrome, exposure to alkylating chemotx, t(15:17)

Answer 10

AML

Question 11

ave age on onset 64, t(9:22), splenomegaly

Answer 11

CML

Question 12

c-myc activation

Answer 12

Burkitts

Question 13

t(11:14), cyclin D1 activation, CD5+, older males

Answer 13

mantle cell lymphoma

Question 14

t(14:18); bcl-2 activation

Answer 14

follicular lymphoma

Question 15

t(15:17)

Answer 15

M3 type of AML

Question 16

incr WBC count with left shift with incr leukocyte ALP is _____; vs incr WBC count with left shift with DECR leukocyte ALP is ______

Answer 16

leukemoid rxn; CML

Question 17

low grade fever, NS, weight loss

Answer 17

B sx - asscd with hodgkin lymphoma

Question 18

hypercalcemia, renal insufficiency, anemia, bone lytic lesions/back pain

Answer 18

multiple myeloma

“CRAB”