cytokines Flashcards
endogenous pyrogen, causes fever, acute inflammation
IL-1
endogenous pyrogen, secreted by TH2, causes fever and stimulates production of acute phase proteins
IL-6
chemotactic factor for neutrophils
IL-8
induces differentiation of T cells into TH1 cells. activates NK cells
IL-12
mediates septic shock
TNF alpha
stimulates growth of helper, cytotoxic, regulatory T cells
IL-2
growth and differentiation of bone marrow stem cells
IL-3
activates NK cells to kill virus infected cells, incr MHC expression and Ag presentation
IFN-gamma
induces differentiation into TH2 cells, promotes B cell growth, enhances class switching to IgE and IgG
IL-4
enhances class switching to IgA, stimulates growth of eosinophils
IL-5
inhibits actions of activated T cells and TH1
IL-10