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BOARDS > antineoplastics > Flashcards

antineoplastics Flashcards

1
Q

which drugs alkylates DNA & causes pulmonary fibrosis

A

Busulfan

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2
Q

which drug fragments DNA, forming free radicals, and causes pulm fibrosis

A

bleomycin

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3
Q

antimetabolites? (4)

A

MTX
5-FU
Cytarabine
6-MP (Azathioprine)

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4
Q

antitumor antibiotics? (3)

A

Dactinomycin
Doxorubicin
Bleomycin

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5
Q

alkylating agents (3)

A

Cyclophosphamide
Nitrosoureas
Busulfan

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6
Q

which drug blocks purine synthesis, and is metabolized by xanthine oxidase?

A

6-MP (azathioprine)

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7
Q

nitrogen mustard that alkylates DNA

A

nitrosoureass

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8
Q

folic acid analog that inhibits dihydrofolate reductase

A

MTX

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9
Q

intercalates DNA, produces oxygen free radicals, cardiotoxic

A

doxorubicin

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10
Q

DNA alkylating agents used in brain cancer

A

nitrosoureas

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11
Q

applied topically for actinic keratosis and BCC?

A

5-FU

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12
Q

tx for childhood tumors (Ewing sarcoma, WT, rhabdomyosarcoma)

A

dactinomycin

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13
Q

______inhibits topoisomerase II; vs ______inhibits topoisomerase I

A

etoposide; topotecan

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14
Q

which drugs blocks the polymerization of microtubules, preventing mitotic spindle formation

A

vincristine

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15
Q

which drug hyperstabilizes polymerized microtubules so they can’t be broken down

A

paclitaxel

“it’s taxing to stay polymerized”

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16
Q

hydroxyurea acts during what phase by inhibiting ribonucleotide reductase?

A

S phase

“Decr DNA synthesis (S-phase specific)”

17
Q

cross links DNA, is nephrotoxic and ototoxic

A

cisplatin

BOARDS (20 decks)

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