Hemantinics Flashcards
Oral Iron
Ferrous Sulfate
Iron deficiency, normal GI absorption
Ferrous Sulfate
Can cause ACUTE IRON toxicity in children
Ferrous Sulfate
IV Iron
Ferric Salts/Dextra
Iron deficiency, GI absorption limited
Iron Dextran
Chronic Renal Disease
Iron Dextran
Extensive CHRONIC anemia
Iron Dextran
SE: rush, fever, phlebitis, arthralgia, bronchospasm, neuro, GI, urticaria, death
Iron Dextran
need this w/ Vitamin B12
-balamin!
Pernicious Anemia USE
Vitamin B12
difference between Folate and Vitamin B12?
B12 will correct neuro abnormalities!
Do not use in pernicious anemia/intrinsic factor deficiency
Folate!
Acute iron toxicity in kids, use
Deferoxamine (Iron chelator)
SE: bloody diarrhea, necrotizing gastroenteritis
Deferoxamine!
SE: HTN, thrombosis
EPO, darbeoietin Alfa
Renal Failure
EPO, dPO alfa
bone marrow cancer, AIDS/HIV
EPO, dPO alfa
Filgrastim
Myeloid GF
Sargramostim (GM-CSF)
Myeloid GF
tx: NEUTROPENIA, Aplastic anemia
Filgrastim, Sargramostim
SE: bone pain, fever, malaise, arthralgia, myalgias
Filgrastim, Sargramostim
Megakaryocyte GF
Oprelvekin (IL-11)
Tx: THROMBOCYTOPENIA, platelet tx, non-myeloid cancers
Oprelvekin
SE: headache, dizziness, dyspnea
Oprelvekin
Microcytic anemia
Iron Deficiency
Macrocytic anemia
Folic acid deficiency
Highest sources of dietary iron
- cereal
- oysters
- chocolate
- beef liver
- lentils
non-heme iron has…
less bioavailability
polyphenols (teas, coffee)
decrease iron bioavailability
Iron therapy is CI:
HEMOLYTIC anemia
Necrot. gastroenteritis, vomiting, ab. pain!, bloody diarrhea, shock, lethargy, dyspnea, severe metabolic acidosis
Acute Iron Toxicity
MEGALOBLASTIC anemia
Vitamin B12 deficiency
Vitamin B12 is produced by
bacteria!
Sources of Folic Acid
Yeast, liver, kidney, green veggies
G-CSF helps to
differentiate neutrophils
GM-CSF helps
granulocytic, erythroid, megakaryocyte, neutrophil, t-cell lines and inflammation
