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Pharm > Anti-coagulants > Flashcards

Anti-coagulants Flashcards

1
Q

Low dose ASA

A

selective for COX1, preserves PGI2

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2
Q

ASA low dose effect

A

inhibits platelet aggregation

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3
Q

ASA mid dose effect

A

Antipyretic, analgesic

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4
Q

ASA high dose effect

A

Anti-inflammatory

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5
Q

salicylism (toxicity)

A

CNS effects: confusion, tinnitus, dizziness, metabolic: respiratory ALKALOSIS, metabolic ACIDOSIS, renal

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6
Q

If use warfarin + NSAID risk

A

BLEEDING!

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7
Q

MOA: ADP receptor inhibitor

A

Clopidogrel/Plavix

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8
Q

MOA: More selective in reducing CV w/ ATHEROSCLEROSIS

A

Clopidogrel/Plavix

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9
Q

MOA: Blocks P2Y1/P2Y12

A

Clopidogrel/Plavix

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10
Q

MOA: GPIIb/IIIa receptor

A

Abciximab

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11
Q

-parin MOA

A

activation of antithrombin III

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12
Q

Heparin form complexes w/

A

Factors: IIa, IXa, Xa

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13
Q

Zero order kinetic

A

Heparin

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14
Q

Inhibits X from activating prothrombin > thrombin

A

Enoxaparin

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15
Q

Initial Tx of PE/PVT

A

-parins

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16
Q

Use Heparin (HMWT) for pts

A

over 300 lbs

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17
Q

SE: THROMBOCYTOPENIA, OSTEOPOROSIS, prolonged bleeding

A

-Parins

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18
Q

MOA: vitamin K antagonist

A

Warfarin

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19
Q

Warfarin forms complexes w/

A

II, VII, IX, V

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20
Q

Slow onset of action

A

Warfarin

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21
Q

PROPHYLAXIS of PE/DVT

A

Warfarin

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22
Q

Warfarin CI:

A 
Protein C deficiency
Preggo!
CYP3A4 drugs:
Barbs
Rifampin!
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23
Q

Direct thrombin inhibitor

A

Dabigatran, -irudins

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24
Q

Prevent stroke and blood clots in pts w/ abnormal heart rhythms

A

Dalbigatran/-irudin family!

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25
Q

Dabigatran antidote

A

idarucizumab

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26
Q

Direct Factor Xa inhibitors

A

-XA-ban! suffix

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27
Q

Reduce stroke in patients w/ A-fib, tx DVT/PE after parenteral anticoagulant

A

-Xabans family!

28
Q

Xabans interactions

A

CYP3A4

29
Q

rapid lysis of thrombi

A

-plase suffix or Urokinase

30
Q

t-PA derrivatives

A

-plase, urokinase

31
Q

coronary artery thrombosis (MI)

A

-plase, urokinase drugs

32
Q

fribronolytic inhibitor

A

aminocaproic acid

33
Q

competitively inhibits plasminogen activation

A

aminocaproic acid

34
Q

CARBOXYLATES II, VII, IX, X

A

Vitamin K1

35
Q

Vitamin K1 AKA

A

phytonadione

36
Q

Vit K deficiency or excess warfarin

A

Vitamin K1

37
Q

Heparin Neutralizer

A

Protamin sulfate

38
Q

Antithrombin III acts on

A

IXa, Xa, IIa

39
Q

Villa

A

IX > IXa, X > Xa

40
Q

recurrent MI, thromboembolic events after MI

A

Warfarin

41
Q

In protein C deficiency, start warfarin w/

A

heparin first!

42
Q

Heparin antidote

A

Protamine

43
Q

SEVERE dvt tx

A

Fibrinolytics

44
Q

ascending thrombophlebitis of iliofemoral vein SEVERE LE EDEMA

A

fibrinolytics

45
Q

Primary Hemostasis

A

Oprelvekin/IL-11

46
Q

Secondary Hemostasis

A

replace vWD; -plase; IXa/X monoclonal ABs, fibronolytic inhibitors, Vit K1

47
Q

Formoterol, Salmeterol risk

A

Black box if not used w/ Steroids!

48
Q

-terol

A

target B2 receptors > bronchodilation!

49
Q

Albuterol, Levalbuterol

A

SABA

50
Q

Formoterol

A

LABA

51
Q

Salmeterol

A

LABA

52
Q

Olodaterol

A

ULABA

53
Q

Vilanterol

A

ULABA

54
Q

COPD use

A

ULABA

55
Q

SE: dysphonia, hoarseness, oropharyngeal candidiasis

A

Inhalant corticosteroids

56
Q

SEVERE ACUTE or SEVERE CHRONIC

A

prednisone, methylprednisone use 5 day or tapered dose

57
Q

SE: pituitary adrenal suppression

A

-prednisone

58
Q

Block ACh at M3 receptor

A

-tropium

59
Q

additive effects, used as adjunct to B2 agonists and steroids

A

muscarinic antagonists/-tropiums

60
Q

inhibits 5-lipoxygenase

A

Leukotriene Sx Inhibitor/Zileuton

61
Q

Leukotriene Antagonists

A

-lukasts

62
Q

block at LTD4

A

-lukasts

63
Q

Exercise induced asthma

A

Montelukast

64
Q

Allergic rhinitis

A

Montelukast

65
Q

Phosphodiesterase inhibitor

A

-phyllines

66
Q

SE: toxicities > excitatory effects in heart

A

-phyllines

67
Q

MOA: reduces serum IgE

A

Omalizumab

Pharm (12 decks)

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