Antianginal Flashcards
1
Q
Nitric Oxide MOA
A
stimulates guanyl cyclase activity
2
Q
NO > guanyl cyclase activity > cGMP…
A
vasodilation! reduced platelet aggregation
3
Q
vasospastic/variant angina
A
nitrate + CCB
4
Q
exertional/exercise-induced angina
A
CCB
5
Q
atrial and AV nodal REENTRANT arrhythmias
A
CCB
6
Q
Hx CAD, post-MI use
A
BBC
7
Q
Can add another CCB to tx ONLY if…
A
NOT using verapamil or diltiazem (negative inotropic effects increase O2 demand)
8
Q
However… pts on dihydropyridine CCB could benefit from adding another to
A
counteract reflex tachycardia
9
Q
Ranolazine MOA
A
inhibits late sodium current Ina, part of delayed IKr
10
Q
Avoid taking Ranolazine w/
A
CYP3A drugs (Ketoconazole!) and prolong QT interval
