Anti-arrhythmic Flashcards
2nd line tx ATRIAL and VENTRICULAR
Class IA
Lupus-like Syndrome
Procainamide
SE tremor
Class IB
IV only IB
Lidocaine
Rapid recovery
Class IB
Slow recovery
Class IC
2nd line VENTRICULAR
Class IB
SE nystagmus, confusion, seizures
Lidocaine
Lidocaine analog
Mexiletine
2nd line ATRIAL (if LV is good)
Class IC
POST-MI
Class II
rate control: A-fib, A-flutter
Class II
Atrial and Ventricular
Class III
rate control: atrial arrhythmias
Class IV
rate control: atrial arrhythmias, inotropic
Digoxin
ACUTE Atrial
Adenosine
Route of Adenosine
IV
SE: corneal deposits, photosensitivity, liver toxicity, pulmonary fibrosis SE
Amiodarone
SE: Cinchonism (headache, tinnitus)
Quinidine
depressed LV function
Class IC
Hypotension and Fluid retention on outset
Carvedilol
B-blocker, drug induced lupus
acebutolol
Torsades
Class IA and Class III
B-blocker less CNS effects
Atenolol
Hypotension w/ reflex tachycardia
Class IV
SE: A-fib
Adenosine
SE: Heart block
Digoxin and Class IV
SE: AV block
Flecainide (Class IC)
Verapamil SE
constipation
K+ channel blocker and B-blocker
Sotalol
exacerbates hypoglycemia in DM
B-blockers
HT emergencies
Carvedilol
Chronic atrial tachycardias
Propafenone
Propafenone SE
Torsades, B-blocker properties: bronchospasm, myocardial suppression, careful in DM
Exercise Induced Angina
Metoprolol
Vasospastic Angina
Nifedipine
Tx: 2nd line chronic SVT
Quinidine
Atrial arrhythmia, NO STRUCTURAL heart disease
Flecainide
Tx: Chronic atrial tachyarrhythmias
Propafenone
Rebound syndromes with abrupt discontinuation
B-Blockers
Tx: 1st line acute and chronic atrial and ventricular arrhythmias!
Amioidarone!
SE: blue-gray skin discoloration
Amioidarone!
Tx: Chronic management of atrial arrhythmias
Sotalol
-ilide
Class III K channel blockers only
ibutilide
ACUTE atrial arrhythmias
dofetilide
CHRONIC atrial arrhythmias
SVT tx
Class IV (CCBs)
Diltiazem better than Verapemil in that it doesn’t have…
reflex tachycardia
ACh sensitive K+ channels
Adenosine
Digoxin SE: bradycardia, SA node arrest, heart block
Atropine!, K+ and pacemaker
Digoxin SE: PVC of ventricular arrhythmia
Digiband
Tx: Chronic, stable angina
Ranolazine
Ranolazine may also help tx
A-fib
Isosorbide Dinitrate overdose can result in
methemoglobinemia!
Nitrates ROA
Sublingual
If Channel Inhibitor, Sinus Node
Ivabradine
Sacubitril/Valsartan combo
Neprilysin Inhibitor
CHF w/ reduced ejection fraction
Sacubitril/Valsartan combo
Phosphodiesterase Inhibitor
Inamrinone/Amrinone
SHORT-term management ADVANCED HF
Inamrinone
stimulates b-1 and b-2 ADRENERGIC receptors
Dobutamine
AV nodal REENTRANT arrhytmias
Digoxin
Digoxin Toxicity Risk
any pH imbalances! (increased sympathetic tone, respiratory disease, thyroid, etc)
B1 agonists
Dopamine, Dobutamine
Short-term management for SERIOUS HF
B1 agonists
enhances vagal tone
Digoxin
Glycosides
Digoxin
B1 agonist w/ tolerance after few days
Dobutamine