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Endo/Repro: Week 4 > Hellkatz: Uterine Drugs > Flashcards

Hellkatz: Uterine Drugs Flashcards

1
Q

What drugs induce labor, control postpartum hemorrhage, produce uterine contractions after a C-section and many ohter things?

A

oxytocics

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2
Q

What stimulates smooth muscle contraction?

A

increased intracellular Ca

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3
Q

Where are oxytocin and pitocin synthesized and secreted?

A

synthesized in paraventricular and supraoptic nuclei of the hypothalamus>
transported via neurons>
secreted from vesicles in PP

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4
Q

What causes the release of oxytocin and pitocin?

A

cervical dilation
mechanical stimulation of vagina/uterus
suckling reflex

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5
Q

What type of receptor do oxytocin and pitocin stimulate?

A

OTR is a GPCR> increases PLC

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6
Q

What recetpor is present in myoepithelial cells of mammary glands, pregnant myometrium and the CNS?

A

OTR

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7
Q

What inhibits the release of oxytocin and pitocin?

A

ethanol

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8
Q

What is used to promote uterine contractions and milk let down?

A

Oxytocin and pitocin

**can also be used as an antidiuretic at high concentrations (like ADH)

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9
Q

Can be oxytocin and pitocin be given orally?

A

NO it’s a peptide so it can’t be

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10
Q

What is the drug of choice for labor induction ?

A

pitocin (synthetic oxytocin)

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11
Q

What is pitocin used for?

A

Post-due date
Augment dysfunctional labor
Speed up labor in risk situations (chronic HTN, preeclampsia)

Milk let down postpartum
stimulate uterine motility postpartum to reduce bleeding

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12
Q

What is synthesized form AA by COX and rises in AF during pregnancy?

A

PGs

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13
Q

What promotes ripening of cervix (d/t numerous biochemical processes that rearrange the collagen molecules) and uterine contraction?

A

PGE2

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14
Q

What causes uterine contractions?

A

PGF2

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15
Q

What reduces oxytocin induced uterine contractions by inhibiting COX and therefore reducing PG production?

A

Indomethacin (NSAID)

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16
Q

What is a natural PGE used to tx hydatidiform mole?

A

Dinoprostone

17
Q

What is a synthetic PGE used to DILATE the cervix and can also be used as an abortificant?

A

Misoprostol

18
Q

What drugs are natural PGF2A?

A

Dinoprost and Carboprost

19
Q

What are PGs responsible for?

A 
hyperalgesia (pain)
inflammation
fever
vomiting
diarrhea
20
Q

What are SE of PGs?

A

flu-like sxs

21
Q

What is the difference between PGER and PGFR?

A 
PGER= Gs coupled
PGFR= Gq > stimulates IP3
22
Q

What drug mediates contraction of the uterus and is used to control postpartum bleeding?

A

Ergonovine-ergometrine

Uterine contractions compress BVs to reduce bleeding

23
Q

What is used to tx migraine HA?

A

ergotamine

24
Q

What drug is a nonselective COX 1/2 inhibitor that decreases PG formation and is used to delay labor short term and is antiinflammatory?

A

NSAID (indomethacin)

25
Q

Prevents seizures associated w/ eclampsia and competes w/ Ca to relax SM

A

Mg Sulfate

26
Q

What is a tocolytic?

A

any drugs used to suppress uterine SM> suppress premature labor

27
Q

Can be used after 20 week to suppress preterm labor but may increase HR, cause pulmonary edema, hyperglycemia nad precipitate MI by increasing O2 demand (by incrased HR)?

A

B2 agonists (terbutaline)

28
Q

What is the MOA of terbutaline?

A

B2 selective agent>
AC>
increased cAMP

29
Q

What drug inhibits OTR inositol triphosphate activation in order to delay labor and has a rapid onset?

A

Oxytocin receptor antagonist (atosiban)

30
Q

Why might atosiban be used over terbutaline?

A

has fewer maternal SE than B2 agonists BUT it may increase fetal mortality…so maybe not.

31
Q

From posterior pituitary
Can induce labor
Reduce postpartum bleeding
Release milk from mammary glands

A

Oxytocin

32
Q

Induces labor

ripens cervix

A

PGs (Dinoprostone, Dinoprost, and Misoprostol)

33
Q

reduces post-partum uterine bleeding (NEVER given to induce labor)

A

Ergonovine

34
Q

vasoconstrictor used for headaches

A

Ergotamine

Endo/Repro: Week 4 (14 decks)

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