Heavy metals: Molybdenum Dr. Shokry

Question 1

Molybdenum toxicosis is more common in which spp as compared to which related heavy metal toxicosis

Answer 1

Cattle vs. Copper in sheep

Question 2

Source of molybdenum toxicosis

Answer 2

excess molybdenum
deficiency of copper
high dietary sulfates increases toxicity
environmental- plant accumulation, industrial etc
soil contamination esp Fl, Ca, Nv, Or

Question 3

What type of toxicity is seen with molybdenosis

Answer 3

chronic

Question 4

which animalst are most susceptible to molybdenum toxicosis

Answer 4

Cattle
can be seen in sheep
horses & pigs are resistant

Question 5

toxicokinetics of molybdenum toxicosis

Answer 5

absorbed from GIT

excreted in milk in toxic levels

Question 6

MoA of molybdenum toxicosis

Answer 6

Copper deficiency

Question 7

CS of molybdenum toxicosis

Answer 7

severe greenish diarrhea w/ gas bubbles no hemorrhage (8-10d following exposure)
spectecled appearance d/t depigmentation of hair around eyes, rough hair coat
diarrhea

Question 8

Lab dx of molybdenum toxicosis

Answer 8

eleveated molybdenum in blood
decr copper in blood
decr cytochrome oxidase activity

Question 9

Tx of molybdenum toxicosis

Answer 9

copper glycinate inj.

copper sulfate in diet