Fungicides Dr. Shokry

Question 1

which fungicide do we see toxicosis with most

Answer 1

pentachlorophenol (PCP)

Question 2

What is most common form of intoxication by pentachlorophenol

Answer 2

inhalation (used as wood preservative) of fumes or licking treated wood

RUP - No longer used for building materials in barns

Question 3

properties of

toxicity of pentachlorophenol

Answer 3

chlorinated hydrocarbon:

lipid soluble, not persistant in water, swage or soil d/t bacterial decomposition

moderately toxic

incr temp, oily or organic solvent vehicles incr toxicity

Question 4

toxicokinetics of pentochlorophenol

Answer 4

readily absorbed from GIT, inhalation & intact skin

wide distribution incl CNS w not to long 1/2 life

metabolized by conjugation to glucuronic acid (remember cats are deficient in this therefore…stays around longer in cats)

glucuronides excreted in urine

Question 5

MoA of pentochlorophenol

Answer 5

uncouples oxidative phosphorylation ⇒ blocks/decr ATP

leads to overheatins, metabolic acidosis & dehydration & seizures

Question 6

CS of pentachlorophenol toxicosis

Answer 6

acute & chronic

can be peracute death

Question 7

lesions of pentachlorophenol toxicosis

Answer 7

rapid rigor mortis, local irritation of skin & mm

pulmonary congestion & edema, dark blood

pathognomonic lesions:

hyperkeratosis of skin in chronic cases

Question 8

tx for pentachlorophenol toxicosis

px

Answer 8

no spec antidote

detox & supportive

if animal survives for 24h fair chance for complete recovery