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Vet Path. > Healing & Repair > Flashcards

Healing & Repair Flashcards

1
Q

Regeneration types

A
  • replacement w/ original cell type
  • replacement w/ CT
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2
Q

Labile cells

A
  • proliferate & continually replace destroyed cells
  • found in: epithelium, hematopoietic cells of spleen, lymphoid organs, bone marrow
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3
Q

Stable cells

A
  • low replication rate, but rapid division can be stimulated
  • found in: parenchymal cells of glandular organs, vasc. endothelial cells, fibroblasts, smooth m., osteoblasts, chondroblasts
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4
Q

Permanent cells

A
  • don’t replicate at all or its insignificant
  • usually replaced by CT
  • found in: nerves, skeletal m., cardiac m.
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5
Q

Injuries in organs mostly made of labile or stable cells are replaced by

A

Regeneration or regen./CT replacement

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6
Q

If an injury is severe and damages the stroma or basement membrane, then ______ replacement more likely

A

CT

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7
Q

Repair by CT replacement

A

1) fibroblastic cells

2) granulation tissue

3) scar formation

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8
Q

24 hrs after injury you see…

A

Fibroblast and vascular endothelial cell proliferation

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9
Q

3-5 days post-injury, you see…

A

Granulation tissue

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10
Q

Components of granulation tissue

A

Fibroblasts and newly formed BV

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11
Q

Angiogenesis/neovascularization

A

New BV formed from budding of pre-existing BV

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12
Q

4 steps of angiogenesis/neovascularization

A
  • enzymatic degrad. of basement membrane
  • endothelial cell migration-> angiogenic stim.
  • endothelial cell prolif.
  • maturation of endothelial cells & organization-> capillary tubes
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13
Q

T or F: granulation tissue has tight gap junctions

A

False, they’re leaky and cause the tissue to be edematous

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14
Q

Myofibroblasts

A
  • fibroblasts of granulation tissue
  • characteristics: indented nuclei, prominent cytoplasmic fibril bundles, increased contractile proteins
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15
Q

Microscopic features of granulation tissue

A
  • lg. amts of macrophages
  • various amts of eosinoph., neutrop., lymph.
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16
Q

Function of macrophages in granulation tissue

A
  • eliminate injurious agent
  • remove extracellular debris
  • blanching of wound
17
Q

Blanching definition

A

collagen fibers accumulate, excess. Vasc. Channels regress, area becomes lighter

18
Q

First intention healing definition

A
  • occurs w/o wound contamination
  • wound edges approx. & close wound
  • ex. Surgical incisions that are sutured closed
19
Q

When suturing a wound, this occurs…

A
  • incision space filled w/ blood and fibrin
  • clot formation
  • clot gets dehydrated -> scab
20
Q

24 hrs after suturing sx incision….

A
  • neutroph. @ edges
  • epith. edges prolif.-> migrate under sceb -> forms thin, continuous epith. layer
21
Q

72 hrs after suturing sx incision…

A
  • predominant cell-> macrophages

-granulation tissue dev. starts

  • presence of collagen fibers (don’t bridge the incision)
  • epithelial cells grow
  • epidermal covering over incision gets thick
22
Q

Day 5 after suturing sx incision…

A
  • granulation tissue and collagen fibers bridge incision
  • epidermis thickness= normal
  • keratinized epithelium
23
Q

Second week of first intention healing

A
  • collagen acc.
  • fibroblast prolif.
  • inflamm. Cells & edema disappear
  • blanching starts
24
Q

End of month 1 of first intentional healing

A
  • CT scar
  • no inflamm. Cells
  • epidermis intact
  • damaged adexnal struct.
  • decr. Tensile strength
25
Q

Second intention healing definition

A
  • regeneration minimal
  • wound filled w/ granulation tissue
  • occurs in more extensive tissue loss (infarction, lg surface wounds, inflammation ulcers)
26
Q

Exuberant Granulation

A
  • aka: equine “Proud Flesh”
  • so much granulation tissue that a mass is formed & lacks epith.
27
Q

Keloid formation

A
  • Lg bulging scars due to collagen
  • happens in darker skinned ppl more frequently

Vet Path. (10 decks)

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