Head and Neck Infections Flashcards
What is ciliary flush
red ring around the iris
What is Hyphema
layering of red blood cells in the anterior chamber.
What is Iridocyclitis
inflammation of the anterior uveal tract including the ciliary body.
What is keratitis?
inflammation of the cornea, usually very painful
What is the uvea?
Includes the iris, ciliary body, and choroid. Very vascular.
What are the common viral causes of conjunctivitis? [6]
Adenovirus HSV Rubella Rubeola Influenza EBV
What is epidemic keratoconjunctivitis? What causes this?
More fulminant and involves the cornea. It is very contagious and due to adenovirus 8, 19, 37. Self limited
What are the common bacterial causes of conjunctivitis? [5]
Chlamydia, Neisseria, Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae.
Presentation of conjunctivitis?
Usually a watery, itchy, red eye. Typically is not painful, nor does it include significant vision loss. Gritty feeling or feeling of sand in eye
With conjunctivitis what does Preauricular lymphadenopathy indicate about the cause of the infection? [3]
Viral
Gonorrhea
Chlamydia
What is trachoma?
Starts as conjunctivitis and progresses to eyelid scarring resulting in the eyelid turning inward (entropion). The eyelashes turn inward (trichiasis) and ulceration of the cornea by abrasions can eventually lead to blindness.
What is Arlt’s line?
the horizontal line of conjunctival scarring found on the superior eyelid. In trachoma
Diagnosis of trachoma?
PCR
Clinical
Treatment of trachoma?
Surgery for trichiasis.
Antibiotics for active infection.
Facial cleanliness.
Environmental improvement.
Systemic erythromycin or tetracycline for 3–4 weeks and subsequent topical erythromycin or tetracycline for 6 months.
What is adult inclusion conjunctivitis?
Chronic follicular conjunctivitis.
Acquired sexually or via inoculation from contaminated secretions.
Due to D-K chlamydia serotypes
Presentation of adult inclusion conjunctivitis
red eye with purulent discharge, preauricular lymphadenopathy, and frequently has a urethritis/cervicitis present.
Treatment of adult inclusion conjunctivitis?
Treat underlying chlamydia infection
Presentation of gonorrhea conjunctivitis?
Marked purulent discharge, red eye, swollen eyelid, preauricular lymphadenopathy, and chemosis, rapidly progressive if untreated.
Treatment of gonorrhea conjunctivitis?
IM ceftriaxone if only conjunctivitis.
If cornea involved, longer treatment course of ceftriaxone.
Concomitant treatment for Chlamydia with azithro.
Requires frequent flushing of eye to remove inflammation and enzymes harmful to the eye.
Empiric treatment for bacterial conjunctivitis
- Topical trimethoprim/polymyxin B
2. bacitracin/polymyxin B.
Treatment of HSV conjunctivitis
Refer to ophthalmology.
If just conjunctivitis, usually no antiviral is necessary.
Need to rule out corneal involvement.
Risk factors for keratitis [cornea inflammation]
- Contact lens use (particularly overnight use or extended-wear lenses).
- Trauma: may be surgical or nonsurgical.
- Diabetes mellitus.
- Immunosuppression.
What organisms invade an intact cornea?
Neisseria, Listeria, and Corynebacterium
Presentation of keratitis?
- Exquisitely painful eye
- Decreased vision, tearing, and corneal edema.
- Foreign body sensation.
- +/- purulent discharge
- Bacterial keratitis frequently has a white infiltrate or “spot” on the cornea.
Work up of keratitis
- Fluorescein used to visualize ulcer or infiltrates.
2. Corneal scrapings and culture should be done with PCR as indicated for viral etiology.
Exam findings in HSV keratitis? [5]
Dendritic lesions Ciliary flush Decreased sensation of the cornea. May have vesicles on the eyelid. Typically unilateral.
Diagnosis of HSV keratitis?
Clinical
PCR scrapings
Treatment of HSV keratitis [3]
Trifluridine, aciclovir, valaciclovir
–> Topical or PO
Presentation of VZV keratitis
Complete loss of sensation of cornea
Dendritic lesions as well
Hutchinson’s sign.
Mgmt of VZV keratitis
ophthalmic exam
Trifluridine, aciclovir, valaciclovir
–> Topical or PO
Bacteria a/w infection following LASIK? [2]
- Nocardia
- Mycobacterium
- -> M. chelonae is most common of the atypical mycobacteria
Common causes of fungal keratitis? [3]
Fusarium [most common], Aspergillus, Candida.
Risk factors for fungal keratitis? [4]
Trauma
immunosuppression
contact lens use
topical steroid use in eye.
Treatment of fungal keratitis due to a mold? [3]
Combination of topical and systemic treatment.
Natamycin, voriconazole, or amphotericin for molds.
Treatment of fungal keratitis due to candida?
Azoles
Combination of topical and systemic treatment.
Risk factors for Acanthamoeba keratitis?
contact lens use (wearing for prolonged periods)
trauma
historically associated with the tablets used to make contact solution at home
Presentation of acanthamoeba keratitis?
Unilateral.
Red eye, pain, and photophobia.
Can have a dendritic lesion, so may be mistaken for HSV.
May have a ring lesion later in course
Diagnosis of Acanthamoeba keratitis?
Calcofluor white stains the trophozoite and the cyst.
plate the scraping on an E. coli lawn.
Treatment of Acanthamoeba keratitis?
Topical polyhexamethylene guanide or chlor-hexidine.
Plus topical propamidine isethionate or hexamidine.
May require keratoplasty
What is uveitis
Inflammation of the iris, ciliary body, choroid, or retina
What is anterior uveitis?
Inflammation of iris, ciliary body, or both called iritis, cyclitis, iridocyclitis respectively.
What is intermediate uveitis?
Inflammation of the viterous and retina
What is posterior uveitis?
Inflammation of the choroid, retina, or both.
Ocular findings in anterior uveitis?
WBCs in aqueous, keratic precipitates, iris nodules, synechiae
Ocular findings in intermediate uveitis?
WBCs or snowballs in the vitreous, pars plana snow bank
Ocular findings in posterior uveitis?
Lesions in choroid, retina, or both; vitritis in some
Ocular findings in panuveitis?
WBCs in aqueous and vitreous
Infectious etiology of anterior uveitis [5]
Herpes simplex (10%) Syphilis (<1%) TB (<1%) Lyme disease (<1%) Leprosy (<1%)
Infectious etiology of intermediate uveitis [1]
Lyme disease (<1%)
Infectious etiology of posterior uveitis [6]
Toxoplasma (25%) CMV (12%) ARN (6%) Toxocara (3%) syphilis (2%) Candida (<1%)
Infectious etiology of panuveitis [3]
Syphilis (6%)
TB (2%)
Candida(2%)
Presentation of anterior uveitis?
Presents as painful red eye with loss of vision.
Presentation of intermediate uveitis
Loss of vision with floaters
Typically painless
–> Usually NOT infectious
Presentation of posterior uveitis?
Usually painless loss of vision.
Presentation of HSV anterior uveitis?
usually a preceding keratitis
unilateral red, painful eye with impaired vision but absence of vesicles.
Decreased sensation of cornea
Treatment of HSV anterior uveitis?
Oral aciclovir, followed by oral suppression.
Topical steroids.
Presentation of VZV anterior uveitis?
Similar to HSV
No preceding keratitis
Cause of acute retinal necrosis and leading cause of progressive outer retinal necrosis
Diagnosis of HSV and VZV anterior uveitis?
PCR of aqueous humor
Treatment of VZV anterior uveitis?
Retinitis present: IV aciclovir followed by oral aciclovir or valaciclovir
Systemic steroids
May require vitrectomy or laser therapy.