Fever Flashcards
What is a fever?
≥38°C (100.4°F) when presuming a basal body temperature of 37°C (98.6°F)
What is hyperpyrexia
Elevated body temperatures, exceeding 41.5°C (>106.7°F)
What are causes of hyperpyrexia?
Severe infections sometimes. Most commonly CNS injury such as stroke, hemorrhage, trauma.
What is ANC <500 called?
Severe neutropenia
How often does bacteremia cause febrile neutropenia?
10-25% of cases.
What is ANC <100 called?
Profound neutropenia.
Common non-infectious causes of fever [8]
- Postsurgical reaction
- DVT
- Stroke
- MI
- Malignancy
- Hemorrhage or hematoma
- Transfusion reactions
- Drug reaction
What are the 3 types of FUO?
- Classic
- Nosocomial
- Immunocompromised
What is classic FUO?
Fevers of…
- 3 weeks
- > 38.3°C at least once.
- Obscure etiology despite baseline work-up
Common infectious causes of classic FUO? [9]
- TB
- Endocarditis
- Osteomyelitis
- Pneumonia
- Occult abscess [abd, dental, perinephric, prostatic]
- Sinusitis
- Zoonoses [Q-fever, Brucellosis]
- CMV / EBV
- STI
Common autoimmune causes of classic FUO? [7]?
- SLE
- Vasculitis
- Adult-onset stills
- Inflammatory arthritides
- IBD
- Sarcoid
- Thyroiditis
Other common causes of classic FUO?
- Lymphoma/leukemia/MM
- Solid stumors [colorectal, breast, liver, lung, testicular, kidney, bone]
- Drugs
- Thromboembolic
- Congenital fever disorder.
What is a nosocomial FUO?
- Fevers >38.3°C
- Start after hospitalization
- Persist at least 3 days.
Infectious causes of nosocomial FUO? [5]
- Pneumonia
- C. diff
- Pyelonephritis
- Device-related infections
- Viral illness
Non-infectious causes of nosocomial FUO? [7]
- DVT / PE
- Ischemia
- Fat emboli
- Bleed
- Hematoma
- Drugs
- Gout
- Transfusion reactions.
