HDV_High_Yield_Flashcards
What is the genome type of Hepatitis D Virus (HDV)?
Circular negative-sense single-stranded RNA (ssRNA) genome, 1.7 kb in size.
What is the structure of HDV?
Icosahedral enveloped virus with an envelope derived from HBV (HBsAg).
Why is HDV referred to as a ‘defective virus’?
HDV is an ‘incomplete RNA virus’ that cannot replicate without HBV.
What is the clinical significance of HDV coinfection with HBV?
Coinfection with HBV increases the severity of the disease and risk of chronicity.
What percentage of HDV cases progress to chronic hepatitis?
90% of HDV cases progress to chronic hepatitis.
What are the primary modes of transmission for HDV?
Bloodborne (needle sharing, transfusions), sexual transmission, and vertical transmission (mother to fetus).
How is HDV diagnosed serologically?
Serological tests detect HDV antigen (Ag) and antibodies (IgM/IgG).
What is the role of PCR in HDV diagnosis?
PCR detects HDV RNA and confirms active infection.
What is a key diagnostic finding in HDV infection?
In blood, HDV (delta agent) is surrounded by HBsAg.
How is HDV prevented?
HDV is prevented indirectly through HBV vaccination, as HDV cannot infect without HBV.
