4.RSV_Flashcards
What are the structural characteristics of RSV?
Lacks HA and NA proteins, paramyxovirus morphology.
What is the incubation period of RSV?
4–5 days.
What are the two most common diseases caused by RSV in infants?
Bronchiolitis and viral pneumonia.
During which season is RSV most commonly seen?
Winter.
How is RSV transmitted?
By respiratory droplets.
What part of the respiratory system does RSV infect and replicate in?
Epithelial cells of the upper respiratory tract (URT).
What are the clinical presentations of RSV in older children versus infants?
Older children: common cold; Infants: Croup, Bronchiolitis, Pneumonia.
Does RSV cause viremia?
No, RSV does not cause viremia.
What is the primary method for diagnosing RSV?
Mainly clinical.
What cell types and effects are observed in RSV culture?
Multinucleated giant cells (MGN) and syncytia formation; observed via cytopathic effect (CPE) in monkey kidney cell culture.
Which serological tests are used to detect RSV antibodies?
ELISA, Immunofluorescence, Complement Fixation Test (CFT).
What confirms RSV infection serologically?
A 4-fold rise in IgG levels.
What is the role of PCR in diagnosing RSV?
Used for definitive viral identification.
What symptomatic treatment is commonly used for RSV?
Nebulizers to relieve congestion and airway issues.
Which antiviral drug is used to treat RSV?
Ribavirin.
